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5w94

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==Crystal structure of Scc4 in complex with Scc2n and Ctf19n==
==Crystal structure of Scc4 in complex with Scc2n and Ctf19n==
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<StructureSection load='5w94' size='340' side='right' caption='[[5w94]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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<StructureSection load='5w94' size='340' side='right'caption='[[5w94]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W94 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w94]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W94 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.193&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xdn|4xdn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [http://pdbe.org/5w94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [http://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w94 OCA], [https://pdbe.org/5w94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w94 RCSB], [https://www.ebi.ac.uk/pdbsum/5w94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w94 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCC4_YEAST SCC4_YEAST]] Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.<ref>PMID:10882066</ref> [[http://www.uniprot.org/uniprot/SCC2_YEAST SCC2_YEAST]] Plays a structural role in chromatin. Involved in sister chromatid cohesion. Forms a complex with SCC4 required for the stable association of the cohesin complex with chromatin, which may act by hydrolyzing ATP from SMC1 and SMC3 heads. Also participates in DNA repair.<ref>PMID:10882066</ref> <ref>PMID:14614819</ref>
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[https://www.uniprot.org/uniprot/SCC4_YEAST SCC4_YEAST] Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes.<ref>PMID:10882066</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Harrison, S C]]
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[[Category: Large Structures]]
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[[Category: Hinshaw, S M]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Cell cycle]]
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[[Category: Harrison SC]]
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[[Category: Centromere]]
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[[Category: Hinshaw SM]]
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[[Category: Cohesin]]
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[[Category: Kinetochore]]
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Current revision

Crystal structure of Scc4 in complex with Scc2n and Ctf19n

PDB ID 5w94

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