5moc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:42, 8 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
-
<StructureSection load='5moc' size='340' side='right' caption='[[5moc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='5moc' size='340' side='right'caption='[[5moc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MOC FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [http://pdbe.org/5moc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [http://www.ebi.ac.uk/pdbsum/5moc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [https://pdbe.org/5moc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [https://www.ebi.ac.uk/pdbsum/5moc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
+
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5moc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5moc" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Andrei, S]]
+
[[Category: Homo sapiens]]
-
[[Category: Leysen, S]]
+
[[Category: Large Structures]]
-
[[Category: Ottmann, C]]
+
[[Category: Andrei S]]
-
[[Category: 14-3-3 p53 c-terminus]]
+
[[Category: Leysen S]]
-
[[Category: Antitumor protein]]
+
[[Category: Ottmann C]]

Current revision

Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide

PDB ID 5moc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5moc"
Personal tools