1j8s

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==PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM==
==PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM==
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<StructureSection load='1j8s' size='340' side='right' caption='[[1j8s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1j8s' size='340' side='right'caption='[[1j8s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1j8s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J8S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1j8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J8S FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8s OCA], [http://pdbe.org/1j8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j8s RCSB], [http://www.ebi.ac.uk/pdbsum/1j8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8s ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j8s OCA], [https://pdbe.org/1j8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j8s RCSB], [https://www.ebi.ac.uk/pdbsum/1j8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j8s ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAPG2_ECOLX PAPG2_ECOLX] Tip adhesin component of type P pili that plays a critical role in kidney infection through targeted interaction with the globoseries glycolipids containing the Gal-alpha(1-4)-Gal disaccharide present on uroepithelial cells (PubMed:11440716, PubMed:31361021). In turn, transcriptionally regulates host gene expression in kidney cells, leading to inflammatory pathway activation and renal tissue damage. Acts thereby as key determinant of invasive uropathogenic E.coli (UPEC), which cause pyelonephritis and urinary-source bacteremia (By similarity).[UniProtKB:A0A0H2VAQ6]<ref>PMID:11440716</ref> <ref>PMID:31361021</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8s_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/1j8s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1j8s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1j8s" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[PapG receptor|PapG receptor]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Dodson, K W]]
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[[Category: Large Structures]]
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[[Category: Hultgren, S J]]
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[[Category: Dodson KW]]
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[[Category: Magnusson, G]]
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[[Category: Hultgren SJ]]
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[[Category: Pinkner, J S]]
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[[Category: Magnusson G]]
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[[Category: Rose, T]]
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[[Category: Pinkner JS]]
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[[Category: Waksman, G]]
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[[Category: Rose T]]
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[[Category: Papg adhesin]]
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[[Category: Waksman G]]
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[[Category: Receptor]]
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[[Category: Structural protein]]
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Current revision

PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM

PDB ID 1j8s

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