Signalosome

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[[4lct]] – hCOP9 subunit 1 – human <br />
[[4lct]] – hCOP9 subunit 1 – human <br />
 +
[[6a73]] – hCOP9 subunit 2 + IP6<br />
[[4d0p]] – hCOP9 subunit 4 <br />
[[4d0p]] – hCOP9 subunit 4 <br />
[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />
[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />
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[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />
[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />
 +
[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />
 +
[[6r7f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />
 +
[[8h3f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM <br />
 +
[[8h38]], [[8h3a]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM <br />
 +
[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />
 +
[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana'' <br />
 +
[[7enf]], [[7ewm]] – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast <br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code 4d10)

Drag the structure with the mouse to rotate

3D Structures of COP9 signalosome

Updated on 20-November-2023

4lct – hCOP9 subunit 1 – human
6a73 – hCOP9 subunit 2 + IP6
4d0p – hCOP9 subunit 4
1ufm – hCOP9 subunit 4 PCI domain - NMR
4f7o – hCOP9 subunit 5
5jog, 5joh, 5m5q – hCOP9 subunit 5 + inhibitor
4qft – hCOP9 subunit 6
4e0q, 4r14 – hCOP9 subunit 6 MPN domain
4d10, 4d18, 4wsn – hCOP9 subunits 1,2,3,4,5,6,7A,8
6r7n, 6r7i, 6r7h – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM
6r7f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM
8h3f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM
8h38, 8h3a – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM
6r6h – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM
3chm – hCOP9 subunit 7 – Arabidopsis thaliana
7enf, 7ewm – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast

References

  1. ↑ Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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