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5oeg

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==Molecular tweezers modulate 14-3-3 protein-protein interactions==
==Molecular tweezers modulate 14-3-3 protein-protein interactions==
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<StructureSection load='5oeg' size='340' side='right' caption='[[5oeg]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='5oeg' size='340' side='right'caption='[[5oeg]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5oeg]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4hru 4hru]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OEG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5oeg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OEG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9SZ:C42+H32+O8+P2'>9SZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oeg OCA], [http://pdbe.org/5oeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oeg RCSB], [http://www.ebi.ac.uk/pdbsum/5oeg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oeg ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oeg OCA], [https://pdbe.org/5oeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oeg RCSB], [https://www.ebi.ac.uk/pdbsum/5oeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oeg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5oeg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5oeg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bier, D]]
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[[Category: Homo sapiens]]
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[[Category: Ottmann, C]]
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[[Category: Large Structures]]
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[[Category: 14-3-3]]
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[[Category: Bier D]]
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[[Category: Inhibition]]
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[[Category: Ottmann C]]
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[[Category: Signaling protein]]
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[[Category: Supramolecular ligand]]
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Current revision

Molecular tweezers modulate 14-3-3 protein-protein interactions

PDB ID 5oeg

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