This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1y8t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:19, 3 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1y8t.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form==
-
|PDB= 1y8t |SIZE=350|CAPTION= <scene name='initialview01'>1y8t</scene>, resolution 2.00&Aring;
+
<StructureSection load='1y8t' size='340' side='right'caption='[[1y8t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
<table><tr><td colspan='2'>[[1y8t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y8T FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00089 Trypsin], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0265 DegQ]</span>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8t OCA], [https://pdbe.org/1y8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y8t RCSB], [https://www.ebi.ac.uk/pdbsum/1y8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y8t ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y8t TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y8t OCA], [http://www.ebi.ac.uk/pdbsum/1y8t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y8t RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/PEPD_MYCTU PEPD_MYCTU] Required for virulence (PubMed:18479146). Acts both as a protease, which degrades and/or refolds damaged substrate targets, and as a chaperone (PubMed:18479146, PubMed:20061478). Plays an important role in the stress response network mediated through the two-component regulatory system MprAB and SigE signaling networks (PubMed:20061478). May utilize its PDZ domain to recognize and process misfolded proteins at the cell membrane, leading to activation of the MprAB and SigE signaling pathways and subsequent establishment of a positive feedback loop that facilitates bacterial adaptation (PubMed:20061478). Interacts with and potentially cleaves several proteins, including the 35 kDa antigen PspA (PubMed:21445360). Proteolytic cleavage of PspA may help to maintain cell envelope homeostasis in Mycobacterium and regulate specific stress response pathways during periods of extracytoplasmic stress (PubMed:21445360). In vitro, exhibits proteolytic activity against the artificial substrate beta-casein (PubMed:18479146, PubMed:20061478).<ref>PMID:18479146</ref> <ref>PMID:20061478</ref> <ref>PMID:21445360</ref>
-
 
+
== Evolutionary Conservation ==
-
'''Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y8/1y8t_consurf.spt"</scriptWhenChecked>
-
1Y8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y8T OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Mycobacterium tuberculosis h37rv]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Single protein]]
+
</jmolCheckbox>
-
[[Category: MohamedMohaideen, N N.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y8t ConSurf].
-
[[Category: Palaninathan, S K.]]
+
<div style="clear:both"></div>
-
[[Category: Sacchettini, J C.]]
+
== References ==
-
[[Category: TBSGC, TB Structural Genomics Consortium.]]
+
<references/>
-
[[Category: protein structure initiative]]
+
__TOC__
-
[[Category: psi]]
+
</StructureSection>
-
[[Category: serine protease]]
+
[[Category: Large Structures]]
-
[[Category: structural genomic]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: tb structural genomics consortium]]
+
[[Category: MohamedMohaideen NN]]
-
[[Category: tbsgc]]
+
[[Category: Palaninathan SK]]
-
 
+
[[Category: Sacchettini JC]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:00:14 2008''
+

Current revision

Crystal Structure of RV0983 from Mycobacterium tuberculosis- Proteolytically active form

PDB ID 1y8t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y8t"
Personal tools