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4yyy

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==X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with uridine==
==X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with uridine==
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<StructureSection load='4yyy' size='340' side='right' caption='[[4yyy]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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<StructureSection load='4yyy' size='340' side='right'caption='[[4yyy]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yyy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YYY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yyy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YYY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yek|4yek]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_phosphorylase Thymidine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.4 2.4.2.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yyy OCA], [https://pdbe.org/4yyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yyy RCSB], [https://www.ebi.ac.uk/pdbsum/4yyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yyy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yyy OCA], [http://pdbe.org/4yyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yyy RCSB], [http://www.ebi.ac.uk/pdbsum/4yyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yyy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY]] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
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[https://www.uniprot.org/uniprot/TYPH_SALTY TYPH_SALTY] The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thymidine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Balaev, V V]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Betzel, C]]
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[[Category: Balaev VV]]
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[[Category: Gabdulkhakov, A G]]
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[[Category: Betzel C]]
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[[Category: Lashkov, A A]]
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[[Category: Gabdulkhakov AG]]
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[[Category: Mikhailov, A M]]
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[[Category: Lashkov AA]]
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[[Category: Metabolism]]
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[[Category: Mikhailov AM]]
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[[Category: Nucleoside]]
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[[Category: Transferase]]
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Current revision

X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with uridine

PDB ID 4yyy

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