1ya0

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[[Image:1ya0.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the N-terminal domain of human SMG7==
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|PDB= 1ya0 |SIZE=350|CAPTION= <scene name='initialview01'>1ya0</scene>, resolution 2.55&Aring;
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<StructureSection load='1ya0' size='340' side='right'caption='[[1ya0]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1ya0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YA0 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ya0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ya0 OCA], [https://pdbe.org/1ya0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ya0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ya0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ya0 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ya0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ya0 OCA], [http://www.ebi.ac.uk/pdbsum/1ya0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ya0 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SMG7_HUMAN SMG7_HUMAN] Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.<ref>PMID:15546618</ref> <ref>PMID:15721257</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ya/1ya0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ya0 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the N-terminal domain of human SMG7'''
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==Overview==
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<references/>
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In metazoa, regulation of the phosphorylation state of UPF1 is crucial for nonsense-mediated mRNA decay (NMD), a process by which aberrant mRNAs containing nonsense mutations are degraded. UPF1 is targeted for dephosphorylation by three related proteins, SMG5, SMG6, and SMG7. We report here the crystal structure of the N-terminal domain of SMG7. The structure reveals that SMG7 contains a 14-3-3-like domain. Residues that bind phosphoserine-containing peptides in 14-3-3 are conserved at the equivalent positions in SMG7. Mutation of these residues impairs UPF1 binding to SMG7 in vitro and UPF1 recruitment to cytoplasmic mRNA decay foci in vivo, suggesting that SMG7 acts as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. The 14-3-3 site of SMG7 is conserved in SMG5 and SMG6. These data also imply that the homologous human Est1 might have a 14-3-3 function at telomeres, and that phosphorylation events may be important for telomerase regulation.
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__TOC__
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</StructureSection>
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==About this Structure==
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1YA0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YA0 OCA].
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==Reference==
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SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway., Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E, Mol Cell. 2005 Feb 18;17(4):537-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721257 15721257]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Conti, E.]]
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[[Category: Conti E]]
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[[Category: Ebert, J.]]
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[[Category: Ebert J]]
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[[Category: Fukuhara, N.]]
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[[Category: Fukuhara N]]
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[[Category: Izaurralde, E.]]
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[[Category: Izaurralde E]]
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[[Category: Lindner, D.]]
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[[Category: Lindner D]]
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[[Category: Unterholzner, L.]]
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[[Category: Unterholzner L]]
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[[Category: 14-3-3]]
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[[Category: alpha-helical repeat]]
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[[Category: tetratricopetide repeat (tpr)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:00:42 2008''
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Current revision

Crystal structure of the N-terminal domain of human SMG7

PDB ID 1ya0

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