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5wie

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==Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state==
==Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state==
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<StructureSection load='5wie' size='340' side='right' caption='[[5wie]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='5wie' size='340' side='right'caption='[[5wie]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WIE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wie OCA], [http://pdbe.org/5wie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wie RCSB], [http://www.ebi.ac.uk/pdbsum/5wie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wie ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wie OCA], [https://pdbe.org/5wie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wie RCSB], [https://www.ebi.ac.uk/pdbsum/5wie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wie ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT]] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. [[http://www.uniprot.org/uniprot/KCNA2_RAT KCNA2_RAT]] Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.<ref>PMID:7544443</ref>
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[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lu, Z]]
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[[Category: Large Structures]]
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[[Category: Pau, V]]
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[[Category: Mus musculus]]
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[[Category: Ramu, Y]]
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[[Category: Rattus norvegicus]]
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[[Category: Xu, Y]]
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[[Category: Lu Z]]
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[[Category: Zhou, Y]]
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[[Category: Pau V]]
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[[Category: Inactivation]]
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[[Category: Ramu Y]]
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[[Category: Ion channel]]
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[[Category: Xu Y]]
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[[Category: Membrane protein]]
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[[Category: Zhou Y]]
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[[Category: Metal transport]]
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[[Category: Voltage-gated]]
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Current revision

Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state

PDB ID 5wie

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