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Signal recognition particle receptor

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<Structure load='' size='400' frame='true' align='right' caption='Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion [[2fh5]]' scene='48/485587/Cv/1' pspeed='8' />
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<StructureSection load='' size='350' side='right' scene='48/485587/Cv/1' caption='Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion [[2fh5]]'>
'''Signal recognition particle receptor''' (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the [[Signal recognition particle protein|signal recognition particle (SRP)]]. SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called '''FtsY'''.
'''Signal recognition particle receptor''' (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the [[Signal recognition particle protein|signal recognition particle (SRP)]]. SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called '''FtsY'''.
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*<scene name='48/485587/Cv/4'>GTP binding site</scene>. Water molecules shown as red spheres.
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See also [[Intracellular receptors]]
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*<scene name='48/485587/Cv/5'>Mg coordination site</scene>.
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==3D structures of signal recognition particle receptor==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*<scene name='48/485587/Cv/6'>GTP binding site</scene>. Water molecules are shown as red spheres.
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*<scene name='48/485587/Cv/7'>Mg coordination site</scene>.
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*Signal recognition particle receptor
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==3D structures of signal recognition particle receptor==
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**[[1nrj]] – ySRPR α+β subunits + GTP – yeast<br />
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**[[2fh5]] - hSRPR α+β subunits + GTP – human<br />
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**[[5l3q]] - hSRPR α subunit + SRP54 + AMP + GNP <br />
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**[[2ged]] - ySRPR β subunit (mutant)<br />
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**[[2go5]] - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - EM<br />
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**[[3dm9]], [[3dmd]], [[3e70 ]]– SRPR + GDP – ''Pyrococcus furiosus''
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*Signal recognition particle receptor FtsY
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[[Signal recognition particle receptor 3D structures]]
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**[[1zu5]], [[1zu4]] – SRPR FtsY NG domain – ''Mycoplasma mycoides''<br />
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</StructureSection>
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**[[1vma]] – SRPR FtsY – ''Thermotoga maritima''<br />
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**[[2yhs]], [[2qy9]], [[1fts]] – EcSRPR FtsY NG domain – ''Escherichia coli''<br />
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**[[2q9a]] – EcSRPR FtsY <br />
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**[[2q9c]], [[2q9b]] – EcSRPR FtsY NG domain + GMPPNP<br />
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**[[2iyl]] – EcSRPR FtsY residues 20-303 + GDP<br />
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**[[2xxa]] - EcSRPR FtsY NG domain + signal recognition particle protein residues 1-433 (mutant) + 4.5SRNA<br />
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**[[3zn8]] - EcSRPR FtsY NG domain + signal recognition particle protein 54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B<br />
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**[[2j7p]], [[1rj9]], [[1okk]] – TaSRPR FtsY NG domain + signal recognition particle protein – ''Thermus aquaticus''<br />
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**[[2cnw]] – TaSRPR FtsY NG domain + signal recognition particle protein + GDP<br />
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**[[4c7o]] – EcFtsY + EcSRP + SRP RNA<br />
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**[[2xkv]] – EcFtsY + EcSRP NG+M domains + 4.5S RNA<br />
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**[[5l3r]] – SRPR FtsY + SRP54 - ''Arabidopsis thaliana''<br />
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**[[5l3w]] – SRPR FtsY NG domain - ''Sulfolobus acidocaldarius''<br />
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**[[5l3s]] – SRPR FtsY + SRP54 + GNP - ''Sulfolobus solfataricus''<br />
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}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion 2fh5

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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