SUMO conjugating enzyme Ubc9
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='SUMO_conjugating_enzyme_Ubc9/Cv/1' caption='SUMO conjugating enzyme Ubc9 tetramer [[2gjd]]'> |
== Function == | == Function == | ||
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*Ubc9 | *Ubc9 | ||
| - | **[[2gjd]] – yUbc9 - yeast<br /> | ||
**[[1a3s]] - hUbc9 - human<br /> | **[[1a3s]] - hUbc9 - human<br /> | ||
**[[5f6e]] – hUbc9 (mutant)<br /> | **[[5f6e]] – hUbc9 (mutant)<br /> | ||
**[[1u9a]] - mUbc9 - mouse<br /> | **[[1u9a]] - mUbc9 - mouse<br /> | ||
**[[1u9b]] - mUbc9 (mutant)<br /> | **[[1u9b]] - mUbc9 (mutant)<br /> | ||
| + | **[[2gjd]] – yUbc9 - yeast<br /> | ||
**[[4jue]], [[4m1n]] – Ubc9 – ''Plasmodium falciparum''<br /> | **[[4jue]], [[4m1n]] – Ubc9 – ''Plasmodium falciparum''<br /> | ||
*Ubc9 complexes | *Ubc9 complexes | ||
| - | **[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br /> | ||
| - | **[[2eke]] – yUbc9+SMT3<br /> | ||
| - | **[[5jne]] – yUbc9 + SMT3 + PCNA + SIZ1<br /> | ||
**[[2xwu]] – hUbc9+importin13 <br /> | **[[2xwu]] – hUbc9+importin13 <br /> | ||
**[[2px9]] – hUbc9+SUMO2<br /> | **[[2px9]] – hUbc9+SUMO2<br /> | ||
| - | **[[2pe6]] - hUbc9+SUMO1<br /> | + | **[[2pe6]], [[8odr]] - hUbc9+SUMO1<br /> |
**[[4y1l]] – hUbc9 + RSUME<br /> | **[[4y1l]] – hUbc9 + RSUME<br /> | ||
| + | **[[6q83]] – hUbc9 + KAP122<br /> | ||
| + | **[[6syf]] – hUbc9 + peptide<br /> | ||
**[[5f6d]], [[5f6u]], [[5f6v]], [[5f6w]], [[5f6x]], [[5f6y]] – hUbc9 (mutant) + inhibitor<br /> | **[[5f6d]], [[5f6u]], [[5f6v]], [[5f6w]], [[5f6x]], [[5f6y]] – hUbc9 (mutant) + inhibitor<br /> | ||
**[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br /> | **[[2o25]], [[2px9]] - hUbc9+ ubiquitin-conjugating enzyme E1<br /> | ||
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**[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br /> | **[[1z5s]] - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2<br /> | ||
**[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + RANBP2<br /> | **[[3uin]], [[3uio]], [[3uip]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + RANBP2<br /> | ||
| - | **[[4w5v]] - hUbc9+ SUMO activating enzyme <br /> | + | **[[4w5v]], [[5fq2]] - hUbc9+ SUMO activating enzyme <br /> |
**[[5d2m]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + ZNF451<br /> | **[[5d2m]] - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + ZNF451<br /> | ||
**[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br /> | **[[2gro]], [[2grp]], [[2grq]], [[2grr]] - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal<br /> | ||
**[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br /> | **[[3a4s]] – hUbc9 + NFATC2-interacting protein ubiquitin-like domain<br /> | ||
**[[2vrr]], [[2uyz]] – mUbc9+SUMO1 <br /> | **[[2vrr]], [[2uyz]] – mUbc9+SUMO1 <br /> | ||
| - | **[[3rcz]] – Ubc9 + DNA repair protein SUMO-like domain – | + | **[[3ong]], [[3onh]] – yUbc9+ubiquitin-conjugating enzyme E1-like <br /> |
| + | **[[2eke]] – yUbc9+SMT3<br /> | ||
| + | **[[5jne]] – yUbc9 + SMT3 + PCNA + SIZ1<br /> | ||
| + | **[[7p47]] – yUbc9 + SMT3 + MMS21 + SMC5<br /> | ||
| + | **[[3rcz]] – Ubc9 + DNA repair protein SUMO-like domain – fission yeast<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of SUMO conjugating enzyme Ubc9
Updated on 10-December-2023
References
- ↑ Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A. Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013, May 2. PMID:23644018 doi:http://dx.doi.org/10.1016/j.molcel.2013.03.027
- ↑ Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH. Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub, 2012 Aug 17. PMID:22904261 doi:http://dx.doi.org/10.1136/annrheumdis-2012-201746
- ↑ Li F, Li X, Kou L, Li Y, Meng F, Ma F. SUMO-conjugating enzyme UBC9 promotes proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2014 Aug;37(4):1134-41. doi: 10.1007/s10753-014-9837-x. PMID:24531852 doi:http://dx.doi.org/10.1007/s10753-014-9837-x
