TATA-Binding Protein

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<StructureSection load='1tgh' size='450' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'>
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<StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'>
== Function ==
== Function ==
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br />
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br />
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{{Clear}}
{{Clear}}
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</StructureSection>
 
== 3D Structures of TATA-binding protein ==
== 3D Structures of TATA-binding protein ==
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[[TATA-binding protein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* TBP
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**[[2z8u]] – TBP – ''Methanococcus janaschii''<br />
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**[[1pcz]] – PwTBP - ''Pyrococcus woesei''<br />
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**[[1vok]] – AtTBP - ''Arabidopsis thaliana''<br />
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**[[1tbp]] – yTBP - yeast<br />
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**[[4b04]] – yTBP (mutant)<br />
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**[[1mp9]] – TBP – ''Sulfolobus acidocaldarius''<br />
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**[[3eik]] – TBP – ''Encephalitozoon cuniculi''
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* TBP+DNA TATA box
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**[[1ytb]] - yTBP + DNA TATA<br />
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**[[1cdw]] - hTBP core domain+ DNA TATA - human<br />
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**[[1tgh]] - hTBP + DNA TATA<br />
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**[[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]], [[1qn3]], [[1qn4]], [[1vto]] - AtTBP + DNA TATA <br />
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* TBP+DNA TATA box +TFIIA
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**[[1rm1]] – yTBP+TFIIA α, β, γ chains+ DNA TATA <br />
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**[[1ytf]] - yTBP+TFIIA + DNA TATA<br />
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**[[1nh2]] – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA<br />
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**[[1nvp]] - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA <br />
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**[[1jfi]] - hTBP C-terminal+ TFIIA NC2+ DNA TATA<br />
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* TBP+DNA TATA box +TFIIB
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**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
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**[[1c9b]] - hTBP C-terminal+TFIIBC+adenovirus major late promoter<br />
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**[[1vol]] – AtTBP+hTFIIB+DNA TATA<br />
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**[[1ais]], [[1d3u]] - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA <br />
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**[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
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* TBP+DNA TATA+TFIIIB
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**[[1ngm]] - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA<br />
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**[[4roc]], [[4rod]], [[4roe]], [[5n9g]] - hTBP + TFIIIB + DNA TATA<br />
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* TBP+DNA TATA+TFIIA+TFIID
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**[[5fur]] - yTBP +TFIIB + TFIID + DNA TATA<br />
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* TBP in RNA polymerase II complex
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**[[5fyw]], [[5fz5]], [[5fmf]], [[4v1n]], [[4v1o]] – yTBP + DNA-directed RNA polymerase II + TFII + DNA<br />
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**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTBP + DNA-directed RNA polymerase II + TFII + DNA<br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh)

Drag the structure with the mouse to rotate

References

  1. ↑ Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
  2. ↑ van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
  3. ↑ Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456

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Ala Jelani, Michal Harel, Eran Hodis, Alexander Berchansky, David Canner

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