5o8n

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(New page: ==Structure of thermolysin at room temperature via a method of acoustically induced rotation.== <StructureSection load='5o8n' size='340' side='right' caption='5o8n, [[Resolution|resol...)
Current revision (09:36, 6 December 2023) (edit) (undo)
 
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==Structure of thermolysin at room temperature via a method of acoustically induced rotation.==
==Structure of thermolysin at room temperature via a method of acoustically induced rotation.==
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<StructureSection load='5o8n' size='340' side='right' caption='[[5o8n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5o8n' size='340' side='right'caption='[[5o8n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5o8n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O8N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5o8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O8N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8n OCA], [http://pdbe.org/5o8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o8n RCSB], [http://www.ebi.ac.uk/pdbsum/5o8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o8n OCA], [https://pdbe.org/5o8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o8n RCSB], [https://www.ebi.ac.uk/pdbsum/5o8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o8n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.
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[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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This paper describes the design, development and successful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for gradual in-fluid sample reorientation about varying axes and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facilitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.
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An acoustic on-chip goniometer for room temperature macromolecular crystallography.,Burton CG, Axford D, Edwards AMJ, Gildea RJ, Morris RH, Newton MI, Orville AM, Prince M, Topham PD, Docker PT Lab Chip. 2017 Nov 10. doi: 10.1039/c7lc00812k. PMID:29124258<ref>PMID:29124258</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5o8n" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Thermolysin|Thermolysin]]
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*[[Thermolysin 3D structures|Thermolysin 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thermolysin]]
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[[Category: Bacillus thermoproteolyticus]]
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[[Category: Axford, D N]]
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[[Category: Large Structures]]
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[[Category: Burton, C]]
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[[Category: Axford DN]]
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[[Category: Docker, P]]
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[[Category: Burton C]]
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[[Category: Prince, M]]
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[[Category: Docker P]]
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[[Category: Topham, P D]]
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[[Category: Prince M]]
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[[Category: Hydrolase]]
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[[Category: Topham PD]]
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[[Category: Zinc protease]]
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Current revision

Structure of thermolysin at room temperature via a method of acoustically induced rotation.

PDB ID 5o8n

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