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3a79

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==Crystal structure of TLR2-TLR6-Pam2CSK4 complex==
==Crystal structure of TLR2-TLR6-Pam2CSK4 complex==
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<StructureSection load='3a79' size='340' side='right' caption='[[3a79]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3a79' size='340' side='right'caption='[[3a79]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a79]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A79 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a79]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A79 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PXS:(2S)-PROPANE-1,2-DIYL+DIHEXADECANOATE'>PXS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a7b|3a7b]], [[3a7c|3a7c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PXS:(2S)-PROPANE-1,2-DIYL+DIHEXADECANOATE'>PXS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri]), Tlr6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a79 OCA], [https://pdbe.org/3a79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a79 RCSB], [https://www.ebi.ac.uk/pdbsum/3a79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a79 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a79 OCA], [http://pdbe.org/3a79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a79 RCSB], [http://www.ebi.ac.uk/pdbsum/3a79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a79 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE]] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref> [[http://www.uniprot.org/uniprot/TLR6_MOUSE TLR6_MOUSE]] Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation.<ref>PMID:19931471</ref>
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[https://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref> [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a79_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a79_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Toll-like Receptors|Toll-like Receptors]]
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bdellostoma burgeri]]
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[[Category: Eptatretus burgeri]]
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[[Category: Jin, M S]]
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[[Category: Large Structures]]
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[[Category: Kang, J Y]]
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[[Category: Mus musculus]]
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[[Category: Lee, J O]]
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[[Category: Synthetic construct]]
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[[Category: Cell membrane]]
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[[Category: Jin MS]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Kang JY]]
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[[Category: Diacyl lipopeptide]]
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[[Category: Lee J-O]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Inflammatory response]]
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[[Category: Innate immunity]]
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[[Category: Leucine rich repeat]]
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[[Category: Leucine-rich repeat]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Toll-like receptor]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of TLR2-TLR6-Pam2CSK4 complex

PDB ID 3a79

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