3a7c
From Proteopedia
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==Crystal structure of TLR2-PE-DTPA complex== | ==Crystal structure of TLR2-PE-DTPA complex== | ||
| - | <StructureSection load='3a7c' size='340' side='right' caption='[[3a7c]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='3a7c' size='340' side='right'caption='[[3a7c]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3a7c]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3a7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A7C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PDK:(10S,13R)-3-{2-[{2-[BIS(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYMETHYL)AMINO]ETHYL}-10-HYDROXY-5,16-DIOXO-13-(TETRADECANOYLOXY)-9,11,15-TRIOXA-3,6-DIAZA-10-PHOSPHANONACOSAN-1-OIC+ACID+10-OXIDE'>PDK</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PDK:(10S,13R)-3-{2-[{2-[BIS(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYMETHYL)AMINO]ETHYL}-10-HYDROXY-5,16-DIOXO-13-(TETRADECANOYLOXY)-9,11,15-TRIOXA-3,6-DIAZA-10-PHOSPHANONACOSAN-1-OIC+ACID+10-OXIDE'>PDK</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a7c OCA], [https://pdbe.org/3a7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a7c RCSB], [https://www.ebi.ac.uk/pdbsum/3a7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a7c ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref> [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a7c_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a7c_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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==See Also== | ==See Also== | ||
| - | *[[Toll-like | + | *[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] |
| - | *[[Variable lymphocyte receptor|Variable lymphocyte receptor]] | + | *[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Eptatretus burgeri]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Toll-like Receptors]] | [[Category: Toll-like Receptors]] | ||
| - | [[Category: Jin | + | [[Category: Jin MS]] |
| - | [[Category: Kang | + | [[Category: Kang JY]] |
| - | [[Category: Lee | + | [[Category: Lee J-O]] |
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Current revision
Crystal structure of TLR2-PE-DTPA complex
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