This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6alk
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of the major beech pollen allergen Fag s 1== | |
| + | <StructureSection load='6alk' size='340' side='right'caption='[[6alk]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6alk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fagus_sylvatica Fagus sylvatica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ALK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ALK FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6alk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6alk OCA], [https://pdbe.org/6alk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6alk RCSB], [https://www.ebi.ac.uk/pdbsum/6alk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6alk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B7TWE6_FAGSY B7TWE6_FAGSY] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Fag s 1 is a member of the Pathogen Related protein family 10 (PR-10) and can elicit cross-reaction with IgE antibodies produced against the birch pollen allergen Bet v 1. The Nuclear Magnetic Resonance (NMR) structure of Fag s 1 is presented along with its dynamic properties. It shares 66% identity with Bet v 1 and exhibits the expected three alpha-helices and seven beta-sheets arranged as a semi-beta barrel and exposing the residues mapped as the Bet v 1 IgE epitope. The structural dynamics of Fag s 1 were monitored on the fast and intermediate timescales, using relaxation rates. The complex dynamics of Fag s 1 are closely related to the internal cavity, and they modulate IgE and ligand binding. | ||
| - | + | Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.,Moraes AH, Asam C, Almeida FCL, Wallner M, Ferreira F, Valente AP Sci Rep. 2018 Jul 12;8(1):10512. doi: 10.1038/s41598-018-28358-1. PMID:30002383<ref>PMID:30002383</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6alk" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Fagus sylvatica]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Almeida FCL]] | ||
| + | [[Category: Asam A]] | ||
| + | [[Category: Ferreira F]] | ||
| + | [[Category: Moraes AH]] | ||
| + | [[Category: Valente AP]] | ||
| + | [[Category: Wallner M]] | ||
Current revision
NMR solution structure of the major beech pollen allergen Fag s 1
| |||||||||||
