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5mz7

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==Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with incorporated Azidohomoalanine==
==Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with incorporated Azidohomoalanine==
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<StructureSection load='5mz7' size='340' side='right' caption='[[5mz7]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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<StructureSection load='5mz7' size='340' side='right'caption='[[5mz7]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mz7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mz7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MZ7 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZH:AZIDOHOMOALANINE'>AZH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mz7 OCA], [http://pdbe.org/5mz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mz7 RCSB], [http://www.ebi.ac.uk/pdbsum/5mz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mz7 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZH:AZIDOHOMOALANINE'>AZH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mz7 OCA], [https://pdbe.org/5mz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mz7 RCSB], [https://www.ebi.ac.uk/pdbsum/5mz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mz7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mz7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mz7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: KUDLINZKI, D]]
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[[Category: Large Structures]]
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[[Category: LEHNER, F]]
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[[Category: Rattus norvegicus]]
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[[Category: LINHARD, V L]]
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[[Category: Kudlinzki D]]
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[[Category: SCHWALBE, H]]
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[[Category: Lehner F]]
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[[Category: SILVERS, R]]
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[[Category: Linhard VL]]
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[[Category: WITT, K]]
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[[Category: Schwalbe H]]
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[[Category: Artificial amino acid]]
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[[Category: Silvers R]]
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[[Category: Azidohomoalanine]]
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[[Category: Witt K]]
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[[Category: Non-standard amino acid]]
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[[Category: Peptide binding protein]]
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[[Category: Psd-95]]
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[[Category: Unnatural amino acid]]
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Current revision

Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with incorporated Azidohomoalanine

PDB ID 5mz7

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