1k5w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:40, 22 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE==
==THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE==
-
<StructureSection load='1k5w' size='340' side='right' caption='[[1k5w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='1k5w' size='340' side='right'caption='[[1k5w]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1k5w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K5W FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1k5w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K5W FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5w OCA], [http://pdbe.org/1k5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k5w RCSB], [http://www.ebi.ac.uk/pdbsum/1k5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k5w ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5w OCA], [https://pdbe.org/1k5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k5w RCSB], [https://www.ebi.ac.uk/pdbsum/1k5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k5w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
+
[https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/1k5w_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/1k5w_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 28: Line 29:
</div>
</div>
<div class="pdbe-citations 1k5w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1k5w" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
+
[[Category: Large Structures]]
-
[[Category: Anderson, R G.W]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Arac, D]]
+
[[Category: Anderson RGW]]
-
[[Category: Fernandez, I]]
+
[[Category: Arac D]]
-
[[Category: Gao, Y]]
+
[[Category: Fernandez I]]
-
[[Category: Gerber, S H]]
+
[[Category: Gao Y]]
-
[[Category: Rizo, J]]
+
[[Category: Gerber SH]]
-
[[Category: Shin, O]]
+
[[Category: Rizo J]]
-
[[Category: Sudhof, T C]]
+
[[Category: Shin O]]
-
[[Category: Ubach, J]]
+
[[Category: Sudhof TC]]
-
[[Category: C2-domain]]
+
[[Category: Ubach J]]
-
[[Category: C2b-domain]]
+
-
[[Category: Calcium-binding]]
+
-
[[Category: Endocytosis-exocytosis complex]]
+
-
[[Category: Neurotransmitter release]]
+
-
[[Category: Phospholipid-binding]]
+
-
[[Category: Synapsis]]
+
-
[[Category: Synaptic vesicle exocytosis]]
+
-
[[Category: Synaptotagmin i]]
+

Current revision

THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE

PDB ID 1k5w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k5w"
Personal tools