2adu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:48, 30 October 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor==
==Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor==
-
<StructureSection load='2adu' size='340' side='right' caption='[[2adu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+
<StructureSection load='2adu' size='340' side='right'caption='[[2adu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2adu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADU FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2adu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADU FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=R20:4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE'>R20</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METAP2, MNPEP, P67EIF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=R20:4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE'>R20</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adu OCA], [https://pdbe.org/2adu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adu RCSB], [https://www.ebi.ac.uk/pdbsum/2adu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adu ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adu OCA], [http://pdbe.org/2adu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2adu RCSB], [http://www.ebi.ac.uk/pdbsum/2adu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2adu ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/AMPM2_HUMAN AMPM2_HUMAN]] Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.<ref>PMID:2511207</ref> <ref>PMID:20521764</ref> <ref>PMID:14534293</ref> <ref>PMID:17636946</ref> Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.<ref>PMID:2511207</ref> <ref>PMID:20521764</ref> <ref>PMID:14534293</ref> <ref>PMID:17636946</ref>
+
[https://www.uniprot.org/uniprot/MAP2_HUMAN MAP2_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adu_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adu_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 30: Line 29:
</div>
</div>
<div class="pdbe-citations 2adu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2adu" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Methionyl aminopeptidase]]
+
[[Category: Large Structures]]
-
[[Category: Chen, W]]
+
[[Category: Chen W]]
-
[[Category: Fisher, P W]]
+
[[Category: Fisher PW]]
-
[[Category: Hansbury, M J]]
+
[[Category: Hansbury MJ]]
-
[[Category: Ho, T F]]
+
[[Category: Ho TF]]
-
[[Category: Hofmann, G A]]
+
[[Category: Hofmann GA]]
-
[[Category: Janson, C A]]
+
[[Category: Janson CA]]
-
[[Category: Johanson, K O]]
+
[[Category: Johanson KO]]
-
[[Category: Johnson, R K]]
+
[[Category: Johnson RK]]
-
[[Category: Kallander, L S]]
+
[[Category: Kallander LS]]
-
[[Category: Kirkpatrick, R B]]
+
[[Category: Kirkpatrick RB]]
-
[[Category: Lu, Q]]
+
[[Category: Lu Q]]
-
[[Category: Mattern, M R]]
+
[[Category: Mattern MR]]
-
[[Category: Meek, T D]]
+
[[Category: Meek TD]]
-
[[Category: Ryan, M D]]
+
[[Category: Ryan MD]]
-
[[Category: Schulz-Pritchard, C K]]
+
[[Category: Schulz-Pritchard CK]]
-
[[Category: Smith, W W]]
+
[[Category: Smith WW]]
-
[[Category: Tew, D]]
+
[[Category: Tew D]]
-
[[Category: Thompson, S K]]
+
[[Category: Thompson SK]]
-
[[Category: Tomaszek, T]]
+
[[Category: Tomaszek T]]
-
[[Category: Veber, D F]]
+
[[Category: Veber DF]]
-
[[Category: Ward, K W]]
+
[[Category: Ward KW]]
-
[[Category: Winkler, J D]]
+
[[Category: Winkler JD]]
-
[[Category: Yang, G]]
+
[[Category: Yang G]]
-
[[Category: Zhang, G F]]
+
[[Category: Zhang GF]]
-
[[Category: Aminopeptidase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Metal binding]]
+
-
[[Category: Protease]]
+

Current revision

Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor

PDB ID 2adu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2adu"
Personal tools