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1tev

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==Crystal structure of the human UMP/CMP kinase in open conformation==
==Crystal structure of the human UMP/CMP kinase in open conformation==
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<StructureSection load='1tev' size='340' side='right' caption='[[1tev]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1tev' size='340' side='right'caption='[[1tev]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1tev]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TEV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1tev]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TEV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TEV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UMP/CMP_kinase UMP/CMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.14 2.7.4.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tev OCA], [https://pdbe.org/1tev PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tev RCSB], [https://www.ebi.ac.uk/pdbsum/1tev PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tev ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tev OCA], [http://pdbe.org/1tev PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tev RCSB], [http://www.ebi.ac.uk/pdbsum/1tev PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tev ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCY_HUMAN KCY_HUMAN]] Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
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[https://www.uniprot.org/uniprot/KCY_HUMAN KCY_HUMAN] Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/te/1tev_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/te/1tev_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Cytidine monophosphate kinase|Cytidine monophosphate kinase]]
*[[Cytidine monophosphate kinase|Cytidine monophosphate kinase]]
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*[[UMP/CMP kinase|UMP/CMP kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: UMP/CMP kinase]]
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[[Category: Large Structures]]
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[[Category: Konrad, M]]
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[[Category: Konrad M]]
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[[Category: Lavie, A]]
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[[Category: Lavie A]]
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[[Category: Ort, S]]
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[[Category: Ort S]]
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[[Category: Segura-Pena, D]]
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[[Category: Segura-Pena D]]
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[[Category: Sekulic, N]]
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[[Category: Sekulic N]]
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[[Category: Conformational change]]
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[[Category: Kinase]]
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[[Category: Lid region]]
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[[Category: Nmp binding region]]
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[[Category: Ploop]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the human UMP/CMP kinase in open conformation

PDB ID 1tev

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