1tq3
From Proteopedia
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==Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein== | ==Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein== | ||
| - | <StructureSection load='1tq3' size='340' side='right' caption='[[1tq3]], [[Resolution|resolution]] 1.89Å' scene=''> | + | <StructureSection load='1tq3' size='340' side='right'caption='[[1tq3]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1tq3]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1tq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq3 OCA], [https://pdbe.org/1tq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq3_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq3_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Kovari | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Saro | + | [[Category: Kovari L]] |
| - | [[Category: Spaller | + | [[Category: Saro D]] |
| - | [[Category: Vickrey | + | [[Category: Spaller M]] |
| - | [[Category: Wawrzak | + | [[Category: Vickrey J]] |
| - | + | [[Category: Wawrzak Z]] | |
Current revision
Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein
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