2ef6
From Proteopedia
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==Canavalia gladiata lectin complexed with Man1-3Man-OMe== | ==Canavalia gladiata lectin complexed with Man1-3Man-OMe== | ||
| - | <StructureSection load='2ef6' size='340' side='right' caption='[[2ef6]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='2ef6' size='340' side='right'caption='[[2ef6]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ef6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef6 OCA], [https://pdbe.org/2ef6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef6_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef6_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2ef6" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Concanavalin 3D structures|Concanavalin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cangl]] | ||
| - | [[Category: Azevedo, W F.de]] | ||
| - | [[Category: Benevides, R G]] | ||
| - | [[Category: Bezerra, G A]] | ||
| - | [[Category: Cavada, B S]] | ||
| - | [[Category: Delatorre, P]] | ||
| - | [[Category: Moreno, F B.M B]] | ||
| - | [[Category: Oliveira, T M]] | ||
| - | [[Category: Rocha, B A.M da]] | ||
| - | [[Category: Souza, E P.de]] | ||
[[Category: Canavalia gladiata]] | [[Category: Canavalia gladiata]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Benevides RG]] |
| - | [[Category: | + | [[Category: Bezerra GA]] |
| - | [[Category: | + | [[Category: Cavada BS]] |
| + | [[Category: Delatorre P]] | ||
| + | [[Category: Moreno FBMB]] | ||
| + | [[Category: Oliveira TM]] | ||
| + | [[Category: Da Rocha BAM]] | ||
| + | [[Category: De Azevedo Jr WF]] | ||
| + | [[Category: De Souza EP]] | ||
Current revision
Canavalia gladiata lectin complexed with Man1-3Man-OMe
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