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1zs0

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==Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)==
==Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)==
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<StructureSection load='1zs0' size='340' side='right' caption='[[1zs0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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<StructureSection load='1zs0' size='340' side='right'caption='[[1zs0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1zs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1zs0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EIN:(1S)-1-{[(4-METHOXY-1,1-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC+ACID'>EIN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP8, CLG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EIN:(1S)-1-{[(4-METHOXY-1,1-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC+ACID'>EIN</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs0 OCA], [https://pdbe.org/1zs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs0 OCA], [http://pdbe.org/1zs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN]] Can degrade fibrillar type I, II, and III collagens.
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1zs0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1zs0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Neutrophil collagenase]]
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[[Category: Large Structures]]
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[[Category: Agamennone, M]]
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[[Category: Agamennone M]]
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[[Category: Campestre, C]]
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[[Category: Campestre C]]
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[[Category: Consalvi, V]]
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[[Category: Consalvi V]]
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[[Category: Gallina, C]]
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[[Category: Gallina C]]
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[[Category: Gavuzzo, E]]
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[[Category: Gavuzzo E]]
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[[Category: Hiller, O]]
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[[Category: Hiller O]]
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[[Category: Mazza, F]]
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[[Category: Mazza F]]
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[[Category: Pochetti, G]]
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[[Category: Pochetti G]]
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[[Category: Tortorella, P]]
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[[Category: Tortorella P]]
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[[Category: Tschesche, H]]
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[[Category: Tschesche H]]
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[[Category: Tucker, P A]]
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[[Category: Tucker PA]]
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[[Category: Hydrolase]]
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[[Category: Phosphonic inhibitor]]
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[[Category: Stereoselective inhibition]]
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[[Category: Sulphonamide junction]]
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Current revision

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer)

PDB ID 1zs0

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