1yqv
From Proteopedia
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==The crystal structure of the antibody Fab HyHEL5 complex with lysozyme at 1.7A resolution== | ==The crystal structure of the antibody Fab HyHEL5 complex with lysozyme at 1.7A resolution== | ||
| - | <StructureSection load='1yqv' size='340' side='right' caption='[[1yqv]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='1yqv' size='340' side='right'caption='[[1yqv]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1yqv]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1yqv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hfl 3hfl] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hfl 2hfl]. The September 2001 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Antibodies'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2001_9 10.2210/rcsb_pdb/mom_2001_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YQV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yqv OCA], [https://pdbe.org/1yqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yqv RCSB], [https://www.ebi.ac.uk/pdbsum/1yqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yqv ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/1yqv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/1yqv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| - | *[[3D structures | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Antibodies]] | [[Category: Antibodies]] | ||
| - | [[Category: | + | [[Category: Gallus gallus]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Cohen | + | [[Category: Cohen GH]] |
| - | [[Category: Davies | + | [[Category: Davies DR]] |
| - | [[Category: Dyda | + | [[Category: Dyda F]] |
| - | [[Category: Padlan | + | [[Category: Padlan EA]] |
| - | [[Category: Silverton | + | [[Category: Silverton EW]] |
| - | [[Category: Wibbenmeyer | + | [[Category: Wibbenmeyer JA]] |
| - | [[Category: Wilson | + | [[Category: Wilson RC]] |
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Current revision
The crystal structure of the antibody Fab HyHEL5 complex with lysozyme at 1.7A resolution
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