1y0h

<StructureSection load='1y0h' size='340' side='right' caption='[[1y0h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[1y0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y0H FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0h OCA], [http://pdbe.org/1y0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y0h RCSB], [http://www.ebi.ac.uk/pdbsum/1y0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0h ProSAT], [http://www.topsan.org/Proteins/TBSGC/1y0h TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/Y0793_MYCTU Y0793_MYCTU]] Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0h_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.,Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:16496224<ref>PMID:16496224</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1y0h" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Cherney, M M]]

[[Category: Ference, C]]

[[Category: Garen, C]]

[[Category: James, M N]]

[[Category: Lemieux, M J]]

[[Category: Structural genomic]]

[[Category: Wang, M]]

[[Category: Alpha+beta sandwich with antiparallel beta-sheet]]

[[Category: Unknown function]]