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1r8y

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==Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)==
==Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)==
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<StructureSection load='1r8y' size='340' side='right' caption='[[1r8y]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='1r8y' size='340' side='right'caption='[[1r8y]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1r8y]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R8Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1r8y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r8x|1r8x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8y OCA], [https://pdbe.org/1r8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8y RCSB], [https://www.ebi.ac.uk/pdbsum/1r8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8y OCA], [http://pdbe.org/1r8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r8y RCSB], [http://www.ebi.ac.uk/pdbsum/1r8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8y ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GNMT_MOUSE GNMT_MOUSE]] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity).<ref>PMID:15340920</ref>
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[https://www.uniprot.org/uniprot/GNMT_MOUSE GNMT_MOUSE] Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity).<ref>PMID:15340920</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8y_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Luka, Z]]
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[[Category: Mus musculus]]
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[[Category: Newcomer, M E]]
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[[Category: Luka Z]]
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[[Category: Pakhomova, S]]
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[[Category: Newcomer ME]]
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[[Category: Wagner, C]]
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[[Category: Pakhomova S]]
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[[Category: Glycine n-methyltransferase]]
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[[Category: Wagner C]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Mouse Glycine N-Methyltransferase (Monoclinic Form)

PDB ID 1r8y

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