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2aun

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==Active site His285Ala mutant of LD-carboxypeptidase==
==Active site His285Ala mutant of LD-carboxypeptidase==
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<StructureSection load='2aun' size='340' side='right' caption='[[2aun]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='2aun' size='340' side='right'caption='[[2aun]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2aun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2aun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zrs|1zrs]], [[2aum|2aum]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Muramoyltetrapeptide_carboxypeptidase Muramoyltetrapeptide carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.13 3.4.17.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aun OCA], [https://pdbe.org/2aun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aun RCSB], [https://www.ebi.ac.uk/pdbsum/2aun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aun ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aun OCA], [http://pdbe.org/2aun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aun RCSB], [http://www.ebi.ac.uk/pdbsum/2aun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aun ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LDC_PSEAE LDC_PSEAE]] Releases the terminal D-alanine residue from the cytoplasmic disaccharide-tetrapeptide GlcNAc-MurNAc-L-Ala-gamma-D-Glu-meso-Dap-D-Ala, which is a murein turnover product. Probably also act on free tetrapetide. May be involved in murein recycling.
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[https://www.uniprot.org/uniprot/LDC_PSEAE LDC_PSEAE] Releases the terminal D-alanine residue from the cytoplasmic disaccharide-tetrapeptide GlcNAc-MurNAc-L-Ala-gamma-D-Glu-meso-Dap-D-Ala, which is a murein turnover product. Probably also act on free tetrapetide. May be involved in murein recycling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aun_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aun_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Muramoyltetrapeptide carboxypeptidase]]
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[[Category: Large Structures]]
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[[Category: Bochtler, M]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Korza, H J]]
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[[Category: Bochtler M]]
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[[Category: Hydrolase]]
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[[Category: Korza HJ]]
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[[Category: Ld-carboxypeptidase]]
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[[Category: Nucleophilic elbow]]
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[[Category: Peptidoglycan hydrolase]]
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[[Category: Serine peptidase]]
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[[Category: Serine-histidine-glutamate triad]]
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Current revision

Active site His285Ala mutant of LD-carboxypeptidase

PDB ID 2aun

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