1z2z

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==Crystal Structure of the Putative tRNA pseudouridine synthase D (TruD) from Methanosarcina mazei, Northeast Structural Genomics Target MaR1==
==Crystal Structure of the Putative tRNA pseudouridine synthase D (TruD) from Methanosarcina mazei, Northeast Structural Genomics Target MaR1==
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<StructureSection load='1z2z' size='340' side='right' caption='[[1z2z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='1z2z' size='340' side='right'caption='[[1z2z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1z2z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_2053 Dsm 2053]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z2Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1z2z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2Z FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">truD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2209 DSM 2053])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2z OCA], [https://pdbe.org/1z2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2z RCSB], [https://www.ebi.ac.uk/pdbsum/1z2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2z ProSAT], [https://www.topsan.org/Proteins/NESGC/1z2z TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2z OCA], [http://pdbe.org/1z2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z2z RCSB], [http://www.ebi.ac.uk/pdbsum/1z2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2z ProSAT], [http://www.topsan.org/Proteins/NESGC/1z2z TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRUD_METMA TRUD_METMA]] Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs (By similarity).
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[https://www.uniprot.org/uniprot/TRUD_METMA TRUD_METMA] Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2z ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2z ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dsm 2053]]
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[[Category: Large Structures]]
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[[Category: Pseudouridylate synthase]]
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[[Category: Methanosarcina mazei]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Ciano, M]]
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[[Category: Ciano M]]
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[[Category: Forouhar, F]]
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[[Category: Forouhar F]]
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[[Category: Hunt, J F]]
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[[Category: Hunt JF]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Tong L]]
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[[Category: Tong, L]]
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[[Category: Yong W]]
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[[Category: Yong, W]]
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[[Category: Alpha-beta protein]]
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[[Category: Lyase]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal Structure of the Putative tRNA pseudouridine synthase D (TruD) from Methanosarcina mazei, Northeast Structural Genomics Target MaR1

PDB ID 1z2z

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