3a8u

<StructureSection load='3a8u' size='340' side='right' caption='[[3a8u]], [[Resolution|resolution]] 1.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[3a8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_putidus"_flugge_1886 "bacillus fluorescens putidus" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A8U FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-alanine--pyruvate_transaminase Beta-alanine--pyruvate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.18 2.6.1.18] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8u OCA], [http://pdbe.org/3a8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a8u RCSB], [http://www.ebi.ac.uk/pdbsum/3a8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8u ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/OAPT_PSEPU OAPT_PSEPU]] Catalyzes transamination between a variety of omega-amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids.<ref>PMID:6822556</ref>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8u_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

The three-dimensional structure of omega-amino acid:pyruvate aminotransferase from Pseudomonas sp. F-126, an isologous alpha 4 tetramer containing pyridoxal 5'-phosphate (PLP) as a cofactor, has been determined at 2.0 A resolution. The diffraction data were collected with a newly developed Weissenberg camera with a Fuji Imaging Plate, using synchrotron radiation. The mean figure-of-merit was 0.57. The subunit is rich in secondary structure and comprises two domains. PLP is located in the large domain. The high homology in the secondary structure between this enzyme and aspartate aminotransferase strongly indicates that these two types of enzymes have evolved from a common ancestor.

Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation.,Watanabe N, Sakabe K, Sakabe N, Higashi T, Sasaki K, Aibara S, Morita Y, Yonaha K, Toyama S, Fukutani H J Biochem. 1989 Jan;105(1):1-3. PMID:2500426<ref>PMID:2500426</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3a8u" style="background-color:#fffaf0;"></div>

[[Category: Bacillus fluorescens putidus flugge 1886]]

[[Category: Beta-alanine--pyruvate transaminase]]

[[Category: Sakabe, K]]

[[Category: Sakabe, N]]

[[Category: Sasaki, K]]

[[Category: Watanabe, N]]

[[Category: Transferase]]