Tubulin tyrosine ligase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Tubulin tyrosine ligase (cyan) complex with α-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code [[4iij]])' scene='70/707399/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
'''Tubulin tyrosine ligase''' (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of α-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated α-tubulin forms Glu-microtubules<ref>PMID:10842328</ref>. The complex of TTL and tubulin contains [[Stathmin]] (STM) - another tubulin-binding protein<ref>PMID:23624152</ref>. | '''Tubulin tyrosine ligase''' (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of α-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated α-tubulin forms Glu-microtubules<ref>PMID:10842328</ref>. The complex of TTL and tubulin contains [[Stathmin]] (STM) - another tubulin-binding protein<ref>PMID:23624152</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='70/707399/Cv/ | + | <scene name='70/707399/Cv/5'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/6'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/7'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>. |
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== 3D Structures of tubulin tyrosine ligase == | == 3D Structures of tubulin tyrosine ligase == | ||
| - | + | [[Tubulin tyrosine ligase 3D structures]] | |
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| - | *Tubulin tyrosine ligase | ||
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| - | **[[3tig]] – fTTL - frog<br /> | ||
| - | **[[3tii]] – fTTL + ATP derivative <br /> | ||
| - | **[[3tin]] – fTTL + ADP <br /> | ||
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| - | *Tubulin tyrosine ligase complex with tubulin | ||
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| - | **[[4iij]] – cTTL + rSTM + tubulin + GTP + GDP - chicken<br /> | ||
| - | **[[4ihj]] – cTTL + rSTM + tubulin + GTP + GDP + ADP <br /> | ||
| - | **[[4wbn]], [[4i55]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative <br /> | ||
| - | **[[5jqg]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative - pig <br /> | ||
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| - | *Tubulin tyrosine ligase complex with tubulin and inhibitor | ||
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| - | [[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br /> | ||
| - | [[4i4t]] – cTTL + rSTM + tubulin + GTP + GDP + zampanolide <br /> | ||
| - | [[4i50]] – cTTL + rSTM + tubulin + GTP + GDP + epothilone <br /> | ||
| - | [[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br /> | ||
| - | [[4o2b]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br /> | ||
| - | [[4o4h]], [[4o4j]], [[4o4i]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br /> | ||
| - | **[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br /> | ||
| - | **[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br /> | ||
| - | **[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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