Uracil glycosylase inhibitor
From Proteopedia
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| - | <StructureSection load='1uug' size=' | + | <StructureSection load='1uug' size='350' side='right' caption='Structure of uracil glycosylase inhibitor (green) complex with uracil DNA glycosylase (cyan) (PDB entry [[1uug]])' scene='51/516470/Cv/1'> |
== Function == | == Function == | ||
'''Uracil glycosylase inhibitor''' or '''uracil-DNA glycosylase inhibitor''' (UGI) is a small protein from ''Bacillus subtilis'' bacteriophage PBS1 which inhibits ''E. coli'' and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes<ref>PMID:12855717</ref>. | '''Uracil glycosylase inhibitor''' or '''uracil-DNA glycosylase inhibitor''' (UGI) is a small protein from ''Bacillus subtilis'' bacteriophage PBS1 which inhibits ''E. coli'' and other species’ uracil DNA glycosylase (UDG). UGI can disassociate UDG:DNA complexes<ref>PMID:12855717</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='51/516470/Cv/ | + | The <scene name='51/516470/Cv/3'>surface interactions between the UDG and UGI is fairly polar</scene><ref>PMID:10080896</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). Interacting UGI residues shown in ball-and-stick representation, UDG residues shown in spacefill representation. |
==3D structures of uracil glycosylase inhibitor== | ==3D structures of uracil glycosylase inhibitor== | ||
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[[1udi]] – UGI + HsvUDG – Herpes simplex virus<br /> | [[1udi]] – UGI + HsvUDG – Herpes simplex virus<br /> | ||
[[2j8x]] - UGI + EBvUDG – Epstein-Barr virus<br /> | [[2j8x]] - UGI + EBvUDG – Epstein-Barr virus<br /> | ||
| + | [[6lyd]], [[6lye]] - UGI + UDG – Bacillus phage PBS2<br /> | ||
[[2zhx]] - UGI + MtUDG – ''Mycobacterium tuberculosis''<br /> | [[2zhx]] - UGI + MtUDG – ''Mycobacterium tuberculosis''<br /> | ||
[[4lyl]] – UDI + UDG – atlantic cod <br /> | [[4lyl]] – UDI + UDG – atlantic cod <br /> | ||
Current revision
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References
- ↑ Acharya N, Kumar P, Varshney U. Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases. Microbiology. 2003 Jul;149(Pt 7):1647-58. PMID:12855717 doi:http://dx.doi.org/10.1099/mic.0.26228-0
- ↑ Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol. 1999 Mar 26;287(2):331-46. PMID:10080896 doi:10.1006/jmbi.1999.2605
