This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Transferrin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:37, 5 March 2020) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='' size='400' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
+
<StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
== Function ==
== Function ==
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].
Line 8: Line 8:
== Structural highlights ==
== Structural highlights ==
-
TF contains <scene name='48/480879/Cv/2'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
+
TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
-
*<scene name='48/480879/Cv/5'>N-lobe Fe coordination</scene>.
+
*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
-
*<scene name='48/480879/Cv/6'>C-lobe Fe coordination</scene>.
+
*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
-
</StructureSection>
+
== 3D Structures of Transferrin ==
== 3D Structures of Transferrin ==
 +
[[Transferrin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*Transferrin
+
-
 
+
-
**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
+
-
**[[4x1d]] – hTF + Yb+3 <br />
+
-
**[[5dyh]] – hTF + Ti+4 <br />
+
-
**[[4h0w]] – hTF + Fe+3 + Bi+3<br />
+
-
**[[1suv]] – hTF + TF receptor <br />
+
-
**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
+
-
 
+
-
*Transferrin N lobe
+
-
 
+
-
**[[1tfd]] – rTF N terminal - rabbit<br />
+
-
**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
+
-
**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
+
-
**[[1ryo]] - hTF N terminal + oxalate
+
-
 
+
-
*Transferrin C lobe
+
-
 
+
-
**[[3skp]] – hTF C terminal<br />
+
-
 
+
-
*Apo transferrin
+
-
 
+
-
**[[1bp5]], [[1btj]] - hTF N terminal<br />
+
-
**[[2hau]], [[2hav]] – hTF (mutant)<br />
+
-
**[[1jnf]] – rTF <br />
+
-
**[[1h76]] – TF - pig
+
-
 
+
-
*Ovotransferrin
+
-
 
+
-
**[[1ovt]], [[1n04]] – cOTF + Fe+3 - chicken<br />
+
-
**[[2d3i]] – cOTF + Al+3<br />
+
-
**[[1dot]] – dOTF + Fe+3 - duck
+
-
 
+
-
*Ovotransferrin N lobe
+
-
 
+
-
**[[1ovb]], [[1gv8]] – dOTF NII domain <br />
+
-
**[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
+
-
**[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
+
-
 
+
-
*Apo ovotransferrin
+
-
**[[1aov]] – dOTF<br />
 
-
**[[1aiv]], [[1ryx]]– cOTF<br />
 
-
**[[1tfa]] - cOTF N terminal<br />
 
-
**[[1iq7]] - cOTF C terminal<br />
 
-
**[[1lfc]] – OTF residues 17-41 – bovine - NMR
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code 3qyt).

Drag the structure with the mouse to rotate

References

  1. ↑ de Jong G, van Dijk JP, van Eijk HG. The biology of transferrin. Clin Chim Acta. 1990 Sep;190(1-2):1-46. PMID:2208733
  2. ↑ Liu YS, Xu GY, Cheng DQ, Li YM. Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease. Hepatobiliary Pancreat Dis Int. 2005 May;4(2):265-8. PMID:15908327
  3. ↑ Yang N, Zhang H, Wang M, Hao Q, Sun H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19. PMID:23256035 doi:10.1038/srep00999

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Transferrin"
Personal tools