5m50

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==Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins==
==Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins==
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<StructureSection load='5m50' size='340' side='right' caption='[[5m50]], [[Resolution|resolution]] 5.30&Aring;' scene=''>
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<SX load='5m50' size='340' side='right' viewer='molstar' caption='[[5m50]], [[Resolution|resolution]] 5.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m50]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M50 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m50]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M50 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m50 OCA], [http://pdbe.org/5m50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m50 RCSB], [http://www.ebi.ac.uk/pdbsum/5m50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m50 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m50 OCA], [https://pdbe.org/5m50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m50 RCSB], [https://www.ebi.ac.uk/pdbsum/5m50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m50 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/F2Z4C1_BOVIN F2Z4C1_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325] [[http://www.uniprot.org/uniprot/CAMP3_MOUSE CAMP3_MOUSE]] Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Akhmanova, A]]
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[[Category: Large Structures]]
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[[Category: Atherton, J]]
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[[Category: Mus musculus]]
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[[Category: Baldus, M]]
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[[Category: Akhmanova A]]
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[[Category: Grant, B J]]
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[[Category: Atherton J]]
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[[Category: Hooff, J J.E van]]
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[[Category: Baldus M]]
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[[Category: Houben, K]]
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[[Category: Grant BJ]]
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[[Category: Hua, S]]
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[[Category: Houben K]]
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[[Category: Jiang, K]]
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[[Category: Hua S]]
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[[Category: Joseph, A P]]
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[[Category: Jiang K]]
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[[Category: Luo, Y]]
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[[Category: Joseph A-P]]
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[[Category: Moores, C A]]
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[[Category: Luo Y]]
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[[Category: Roberts, A J]]
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[[Category: Moores CA]]
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[[Category: Scarabelli, G]]
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[[Category: Roberts AJ]]
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[[Category: Stangier, M M]]
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[[Category: Scarabelli G]]
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[[Category: Steinmetz, M O]]
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[[Category: Stangier MM]]
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[[Category: Topf, M]]
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[[Category: Steinmetz MO]]
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[[Category: Camsap ckk microtubule tubulin]]
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[[Category: Topf M]]
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[[Category: Structural protein]]
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[[Category: Van Hooff JJE]]

Current revision

Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins

5m50, resolution 5.30Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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