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2g09

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==X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product complex==
==X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product complex==
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<StructureSection load='2g09' size='340' side='right' caption='[[2g09]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2g09' size='340' side='right'caption='[[2g09]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2g09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G09 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2g09]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G09 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bdu|2bdu]], [[2g06|2g06]], [[2g07|2g07]], [[2g08|2g08]], [[2g0a|2g0a]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g09 OCA], [https://pdbe.org/2g09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g09 RCSB], [https://www.ebi.ac.uk/pdbsum/2g09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g09 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NT5C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysophospholipase Lysophospholipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.5 3.1.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g09 OCA], [http://pdbe.org/2g09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g09 RCSB], [http://www.ebi.ac.uk/pdbsum/2g09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g09 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5NT3_MOUSE 5NT3_MOUSE]] Can act both as nucleotidase and as phosphotransferase (By similarity).
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[https://www.uniprot.org/uniprot/5NT3A_MOUSE 5NT3A_MOUSE] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.[UniProtKB:Q9H0P0]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g09_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g09_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Lysophospholipase]]
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[[Category: Mus musculus]]
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[[Category: Bingman, C A]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E]]
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[[Category: Bitto E]]
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[[Category: Structural genomic]]
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[[Category: Phillips Jr GN]]
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[[Category: Phillips, G N]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G E]]
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[[Category: Aah38029]]
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[[Category: Bc038029]]
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[[Category: Cesg]]
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[[Category: Cytosolic 5'-nucleotidase iii]]
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[[Category: Hydrolase]]
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[[Category: Lead poisoning]]
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[[Category: Mm 158936]]
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[[Category: Nt5c3 protein]]
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[[Category: P5n-1]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Pyrimidine 5'-nucleotidase 1]]
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[[Category: Umph-1]]
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[[Category: Uniprot q9d020]]
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Current revision

X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product complex

PDB ID 2g09

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