2ocw

From Proteopedia

(Difference between revisions)

Current revision

Solution structure of human secretory component

Structural highlights

2ocw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray solution scattering
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PIGR_HUMAN This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Secretory component (SC) in association with polymeric IgA (pIgA) forms secretory IgA, the major antibody active at mucosal surfaces. SC also exists in the free form, with innate-like neutralizing properties against pathogens. Free SC consists of five glycosylated variable (V)-type Ig domains (D1-D5), whose structure was determined by x-ray and neutron scattering, ultracentrifugation, and modeling. With a radius of gyration of 3.53-3.63 nm, a length of 12.5 nm, and a sedimentation coefficient of 4.0 S, SC possesses an unexpected compact structure. Constrained scattering modeling based on up to 13,000 trial models shows that SC adopts a J-shaped structure in which D4 and D5 are folded back against D2 and D3. The seven glycosylation sites are located on one side of SC, leaving known IgA-binding motifs free to interact with pIgA. This work represents the first analysis of the three-dimensional structure of full-length free SC and paves the way to a better understanding of the association between SC and its potential ligands, i.e. pIgA and pathogenic-associated motifs.

Solution structure of human secretory component and implications for biological function.,Bonner A, Perrier C, Corthesy B, Perkins SJ J Biol Chem. 2007 Jun 8;282(23):16969-80. Epub 2007 Apr 11. PMID:17428798^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bonner A, Perrier C, Corthesy B, Perkins SJ. Solution structure of human secretory component and implications for biological function. J Biol Chem. 2007 Jun 8;282(23):16969-80. Epub 2007 Apr 11. PMID:17428798 doi:http://dx.doi.org/10.1074/jbc.M701281200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ocw"

@@ Line 1: / Line 1: @@
 ==Solution structure of human secretory component==
-<StructureSection load='2ocw' size='340' side='right' caption='[[2ocw]]' scene=''>
+<StructureSection load='2ocw' size='340' side='right'caption='[[2ocw]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ocw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OCW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ocw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCW FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iga|1iga]], [[1r70|1r70]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocw OCA], [https://pdbe.org/2ocw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocw RCSB], [https://www.ebi.ac.uk/pdbsum/2ocw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocw ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocw OCA], [http://pdbe.org/2ocw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ocw RCSB], [http://www.ebi.ac.uk/pdbsum/2ocw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
+[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2ocw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/2ocw_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 29: / Line 28: @@
 </div>
 <div class="pdbe-citations 2ocw" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[IgA|IgA]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Bonner, A]]
+[[Category: Large Structures]]
-[[Category: Corthesy, B]]
+[[Category: Bonner A]]
-[[Category: Perkins, S J]]
+[[Category: Corthesy B]]
-[[Category: Perrier, C]]
+[[Category: Perkins SJ]]
-[[Category: Antibody]]
+[[Category: Perrier C]]
-[[Category: Immune system]]
-[[Category: Immunity]]
-[[Category: Immunoglobulin]]
-[[Category: Sc]]
-[[Category: Secretory]]

2ocw

From Proteopedia

Current revision

Solution structure of human secretory component

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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