2onb

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==Human Thymidylate Synthase at low salt conditions with PDPA bound==
==Human Thymidylate Synthase at low salt conditions with PDPA bound==
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<StructureSection load='2onb' size='340' side='right' caption='[[2onb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='2onb' size='340' side='right'caption='[[2onb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2onb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PA:PROPANE-1,3-DIYLBIS(PHOSPHONIC+ACID)'>7PA</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ypv|1ypv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [https://pdbe.org/2onb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [https://www.ebi.ac.uk/pdbsum/2onb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onb OCA], [http://pdbe.org/2onb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2onb RCSB], [http://www.ebi.ac.uk/pdbsum/2onb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2onb ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2onb_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2onb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2onb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gibson, L M]]
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[[Category: Large Structures]]
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[[Category: Lebioda, L]]
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[[Category: Gibson LM]]
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[[Category: Lovelace, L L]]
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[[Category: Lebioda L]]
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[[Category: Diphosphonic acid]]
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[[Category: Lovelace LL]]
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[[Category: Fdump]]
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[[Category: Heteroinhibition]]
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[[Category: Transferase]]
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[[Category: Zd9331]]
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Current revision

Human Thymidylate Synthase at low salt conditions with PDPA bound

PDB ID 2onb

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