2opg

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==The crystal structure of the 10th PDZ domain of MPDZ==
==The crystal structure of the 10th PDZ domain of MPDZ==
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<StructureSection load='2opg' size='340' side='right' caption='[[2opg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='2opg' size='340' side='right'caption='[[2opg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2opg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OPG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2opg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opg OCA], [http://pdbe.org/2opg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2opg RCSB], [http://www.ebi.ac.uk/pdbsum/2opg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2opg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opg OCA], [https://pdbe.org/2opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opg RCSB], [https://www.ebi.ac.uk/pdbsum/2opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
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[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opg_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opg_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Berridge, G]]
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[[Category: Arrowsmith CH]]
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[[Category: Doyle, D A]]
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[[Category: Berridge G]]
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[[Category: Edwards, A]]
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[[Category: Doyle DA]]
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[[Category: Elkins, J]]
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[[Category: Edwards A]]
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[[Category: Gileadi, C]]
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[[Category: Elkins J]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi C]]
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[[Category: Gorrec, F]]
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[[Category: Gileadi O]]
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[[Category: Papagrigoriou, E]]
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[[Category: Gorrec F]]
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[[Category: Phillips, C]]
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[[Category: Papagrigoriou E]]
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[[Category: Structural genomic]]
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[[Category: Phillips C]]
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[[Category: Salah, E]]
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[[Category: Salah E]]
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[[Category: Savitsky, P]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Ugochukwu, E]]
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[[Category: Ugochukwu E]]
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[[Category: Umeano, C]]
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[[Category: Umeano C]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Sgc]]
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[[Category: Structural protein]]
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Current revision

The crystal structure of the 10th PDZ domain of MPDZ

PDB ID 2opg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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