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2p8e

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==Crystal structure of the serine/threonine phosphatase domain of human PPM1B==
==Crystal structure of the serine/threonine phosphatase domain of human PPM1B==
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<StructureSection load='2p8e' size='340' side='right' caption='[[2p8e]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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<StructureSection load='2p8e' size='340' side='right'caption='[[2p8e]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2p8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2p8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.816&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPM1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8e OCA], [https://pdbe.org/2p8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8e RCSB], [https://www.ebi.ac.uk/pdbsum/2p8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2p8e TOPSAN]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8e OCA], [http://pdbe.org/2p8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p8e RCSB], [http://www.ebi.ac.uk/pdbsum/2p8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8e ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2p8e TOPSAN]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PPM1B_HUMAN PPM1B_HUMAN] 2p21 microdeletion syndrome.
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== Function ==
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[https://www.uniprot.org/uniprot/PPM1B_HUMAN PPM1B_HUMAN] Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.<ref>PMID:18930133</ref> <ref>PMID:22750291</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2p8e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2p8e" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Serine/threonine protein phosphatase|Serine/threonine protein phosphatase]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Bain, K T]]
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[[Category: Bain KT]]
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[[Category: Bonanno, J B]]
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[[Category: Bonanno JB]]
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[[Category: Burley, S K]]
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[[Category: Burley SK]]
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[[Category: Freeman, J]]
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[[Category: Freeman J]]
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[[Category: Lau, C]]
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[[Category: Lau C]]
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[[Category: Structural genomic]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M]]
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[[Category: Smith D]]
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[[Category: Smith, D]]
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[[Category: Wasserman S]]
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[[Category: Wasserman, S]]
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[[Category: Xu W]]
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[[Category: Xu, W]]
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[[Category: Hydrolase]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of the serine/threonine phosphatase domain of human PPM1B

PDB ID 2p8e

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