2p9w

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==Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1==
==Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1==
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<StructureSection load='2p9w' size='340' side='right' caption='[[2p9w]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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<StructureSection load='2p9w' size='340' side='right'caption='[[2p9w]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2p9w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P9W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2p9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P9W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mala s1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=76777 ATCC 96803])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9w OCA], [http://pdbe.org/2p9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p9w RCSB], [http://www.ebi.ac.uk/pdbsum/2p9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p9w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9w OCA], [https://pdbe.org/2p9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p9w RCSB], [https://www.ebi.ac.uk/pdbsum/2p9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p9w ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6WIF3_MALSM Q6WIF3_MALSM]
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Atopic eczema (AE) is a chronic inflammatory disease in which genetic predisposition and environmental factors such as microorganisms contribute to the symptoms. The yeast Malassezia Sympodialis, part of the normal human cutaneous flora, can act as an allergen eliciting specific IgE and T-cell reactivity in patients with AE. The major M. sympodialis allergen Mala s 1 is localized mainly in the yeast cell wall and exposed on the cell surface. Interestingly, Mala s 1 does not exhibit any significant sequence homology to known proteins. Here we present the crystal structure of Mala s 1 determined by single-wavelength anomalous dispersion techniques using selenomethionine-substituted Mala s 1. Mala s 1 folds into a 6-fold beta-propeller, a novel fold among allergens. The putative active site of Mala s 1 overlaps structurally to putative active sites in potential homologues, Q4P4P8 and Tri 14, from the plant parasites Ustilago maydis and Gibberella zeae, respectively. This resemblance suggests that Mala s 1 and the parasite proteins may have similar functions. In addition, we show that Mala s 1 binds to the phosphoinositides (PI) PI(3)P, PI(4)P, and PI(5)P, lipids possibly playing a role in the localization of Mala s 1 to the cell surface. The crystal structure of Mala s 1 will provide insights into the role of this major allergen in the host-microbe interactions and induction of an allergic response in AE.
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Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens.,Vilhelmsson M, Zargari A, Crameri R, Rasool O, Achour A, Scheynius A, Hallberg BM J Mol Biol. 2007 Jun 15;369(4):1079-86. Epub 2007 Apr 12. PMID:17481656<ref>PMID:17481656</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2p9w" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 96803]]
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[[Category: Large Structures]]
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[[Category: Achour, A]]
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[[Category: Malassezia sympodialis]]
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[[Category: Crameri, R]]
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[[Category: Achour A]]
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[[Category: Hallberg, B M]]
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[[Category: Crameri R]]
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[[Category: Rasool, O]]
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[[Category: Hallberg BM]]
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[[Category: Scheynius, A]]
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[[Category: Rasool O]]
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[[Category: Vilhelmsson, M]]
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[[Category: Scheynius A]]
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[[Category: Zargari, A]]
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[[Category: Vilhelmsson M]]
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[[Category: Allergen]]
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[[Category: Zargari A]]
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[[Category: Beta propeller]]
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Current revision

Crystal Structure of the Major Malassezia sympodialis Allergen Mala s 1

PDB ID 2p9w

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