2pe5

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==Crystal Structure of the Lac Repressor bound to ONPG in repressed state==
==Crystal Structure of the Lac Repressor bound to ONPG in repressed state==
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<StructureSection load='2pe5' size='340' side='right' caption='[[2pe5]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='2pe5' size='340' side='right'caption='[[2pe5]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pe5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PE5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pe5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PE5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=145:1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE'>145</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2paf|2paf]], [[2p9h|2p9h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=145:1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE'>145</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lacI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pe5 OCA], [https://pdbe.org/2pe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pe5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pe5 OCA], [http://pdbe.org/2pe5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pe5 RCSB], [http://www.ebi.ac.uk/pdbsum/2pe5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pe5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI]] Repressor of the lactose operon. Binds allolactose as an inducer.
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[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pe5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pe5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2pe5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2pe5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Lac repressor|Lac repressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Daber, R]]
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[[Category: Large Structures]]
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[[Category: Lewis, M]]
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[[Category: Synthetic construct]]
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[[Category: Rosenberg, A]]
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[[Category: Daber R]]
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[[Category: Stayrook, S E]]
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[[Category: Lewis M]]
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[[Category: Allosteric effector]]
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[[Category: Rosenberg A]]
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[[Category: Dna-binding]]
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[[Category: Stayrook SE]]
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[[Category: Gene regulation]]
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[[Category: Lac repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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Current revision

Crystal Structure of the Lac Repressor bound to ONPG in repressed state

PDB ID 2pe5

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