5ex7
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA== | ==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA== | ||
| - | <StructureSection load='5ex7' size='340' side='right' caption='[[5ex7]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='5ex7' size='340' side='right'caption='[[5ex7]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila Drosophila] and [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EX7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ex7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex7 OCA], [https://pdbe.org/5ex7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ex7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ex7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ex7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Drosophila]] |
| - | [[Category: | + | [[Category: Drosophila melanogaster]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Liu CP]] |
| - | [[Category: | + | [[Category: Wang M]] |
| - | [[Category: | + | [[Category: Wang Y]] |
| - | [[Category: | + | [[Category: Xu RM]] |
| - | [[Category: | + | [[Category: Yang N]] |
| - | [[Category: | + | [[Category: Yu Z]] |
Current revision
Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA
| |||||||||||
Categories: Drosophila | Drosophila melanogaster | Large Structures | Liu CP | Wang M | Wang Y | Xu RM | Yang N | Yu Z
