Antigen 85
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 12: | Line 12: | ||
The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. | The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. | ||
| - | *<scene name='70/706736/Cv/ | + | *<scene name='70/706736/Cv/5'>Click here to see active site</scene>.<ref>PMID:15192106</ref> |
| - | + | ||
| - | + | ||
== 3D Structures of antigen 85 == | == 3D Structures of antigen 85 == | ||
| + | [[Antigen 85 3D structures]] | ||
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | **[[1dqz]] – Mt85C <br /> | ||
| - | **[[4mql]], [[4qdx]], [[4qdz]], [[4qe3]], [[4qek]] – Mt85C (mutant)<br /> | ||
| - | **[[1dqy]] – Mt85C + diethyl phosphate inhibitor <br /> | ||
| - | **[[4mqm]], [[4qdu]] – Mt85C + ebselen inhibitor <br /> | ||
| - | **[[4qdo]] – Mt85C + chloromercurybenzoate inhibitor <br /> | ||
| - | **[[4qdt]] – Mt85C + iodoacetamide inhibitor <br /> | ||
| - | **[[1va5]] – Mt85C + octyl glucoside <br /> | ||
| - | **[[3hrh]] – Mt85C + glycerol <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. J Biol Chem. 2004 Aug 27;279(35):36771-7. Epub 2004 Jun 10. PMID:15192106 doi:http://dx.doi.org/10.1074/jbc.M400811200
