BRCA
From Proteopedia
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| - | <StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/ | + | <StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/4' pspeed='8'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='75/750267/Cv/ | + | The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>. |
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| + | ==3D structures of BRCA== | ||
| + | [[BRCA 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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| - | ==3D structures of BRCA1== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[4ofb]], [[4y18]], [[4y2g]], [[4u4a]], [[4jlu]], [[4ifi]], [[4igk]], [[3k0h]], [[3k0k]], [[3coj]], [[1y98]], [[1t15]], [[1t29]], [[1t2v]] - hBRCA1 BRCT1 domain + peptide inhibitor - human<br /> | ||
| - | [[3pxa]], [[3pxb]], [[3pxc]], [[3pxd]], [[3pxe]], [[3k15]], [[3k16]] - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor<br /> | ||
| - | [[1jnx]] - hBRCA1 BRCT domain<br /> | ||
| - | [[2ing]], [[1t2u]], [[1n5o]] - hBRCA1 BRCT1 domain (mutant)<br /> | ||
| - | [[1oqa]] - hBRCA1 BRCT-C domain - NMR<br /> | ||
| - | [[1l0b]] - BRCA1 BRCT domain - rat<br /> | ||
| - | [[2n9e]] - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR<br /> | ||
| - | [[4mkf]], [[4mkg]] - hBRCA1 SUMO-interacting motif - NMR<br /> | ||
| - | [[1jm7]] - hBRCA1 Ring domain + BARD1 ring domian - NMR<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
- ↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m
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