Cytochrome c peroxidase

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<StructureSection load='1dcc' size='350' side='right' caption='Yeast heme-containing cytochrome c peroxidase complex with O2 (PDB entry [[1dcc]])' scene='46/466465/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Yeast heme-containing cytochrome c peroxidase complex with O2 (PDB entry [[1dcc]])' scene='46/466465/Cv/1'>
'''Cytochrome c peroxidase''' (CcP) is a protoporphyrin-containing enzyme which reduces hydrogen peroxide to water.<ref>PMID:17027371</ref>
'''Cytochrome c peroxidase''' (CcP) is a protoporphyrin-containing enzyme which reduces hydrogen peroxide to water.<ref>PMID:17027371</ref>
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See also [[Hemeproteins]].
== Structural highlights ==
== Structural highlights ==
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The <scene name='46/466465/Cv/2'>O2 molecule in the active site coordinates with the heme</scene> (PDB entry [[1dcc]]).<ref>PMID:7664080</ref>
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The <scene name='46/466465/Cv/3'>O2 molecule in the active site coordinates with the heme</scene> (PDB entry [[1dcc]]).<ref>PMID:7664080</ref> Water molecules are shown as red spheres.
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</StructureSection>
 
== 3D Structures of cytochrome c peroxidase ==
== 3D Structures of cytochrome c peroxidase ==
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[[Cytochrome c peroxidase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*CcP
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**[[2cyp]], [[1ccp]], [[1cca]], [[1ccb]], [[1ccc]], [[1cmq]], [[1cce]], [[1ccg]], [[2cep]], [[1cmt]], [[1cmu]], [[3ccx]], [[4ccx]], [[1bek]], [[1bem]], [[1bep]], [[1beq]], [[1bes]], [[1kok]], [[1zby]], [[1zbz]], [[1s73]], [[1sbm]], [[1z53]], [[2ia8]], [[2xil]], [[2xj5]], [[2xj8]], [[2ycg]], [[3r98]], [[3r99]], [[4jb4]], [[4cvi]], [[4cvj]], [[4xva]], [[5d6m]] – yCcP – yeast<br />
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**[[2ccp]], [[3ccp]], [[4ccp]], [[5ccp]], [[6ccp]], [[7ccp]], [[1cyf]], [[1ryc]], [[1cci]], [[1aa4]], [[1ccj]], [[1bej]], [[1a2f]], [[1a2g]], [[1cck]], [[1ccl]], [[1bj9]], [[1dj1]], [[1jci]], [[1kxm]], [[1kxn]], [[1mk8]], [[1mkq]], [[1mkr]], [[1sog]], [[1stq]], [[2v23]], [[3e2n]], [[3e2o]], [[3m23]], [[3m25]], [[3m26]], [[3m27]], [[3m28]], [[3m29]], [[3m2a]], [[3m2b]], [[3m2c]], [[3m2d]], [[3m2e]], [[3m2f]], [[3m2g]], [[3m2h]], [[3m2i]], [[2x07]], [[2x08]], [[4a7m]], [[4nva]], [[4oq7]], [[4xv4]], [[4xv5]], [[4xv6]], [[4xv7]], [[4xv8]], [[5ejt]], [[5ejx]] – yCcP (mutant) <br />
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**[[1ml2]] - yCcP (mutant) with Zn-oxo-protoporphyrin<br />
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**[[1ebe]] – yCcP – Laue<br />
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**[[4dy9]] - CcP - ''Leishmania major''
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*CcP containing di-haem
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**[[1eb7]], [[2vhd]] – CcP – ''Pseudomonas aeruginosa''<br />
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**[[1nml]], [[1rz5]], [[1rz6]] – CcP – ''Marinobacter hydrocarbonoclasticus''<br />
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**[[1zzh]] – CcP – ''Rhodobacter capsulatus''<br />
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**[[1c1u]], [[1c1v]], [[2c1u]], [[2c1v]] – CcP – ''Paracoccus pantotrophus''<br />
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**[[1iqc]] - CcP – ''Nitrosomonas europaea''<br />
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*CcP complex with cytochrome C
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**[[2pcb]], [[1u75]], [[4nfg]] – yCcP + cytochrome C<br />
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**[[2pcc]] - yCcP + iso-1-cytochrome C<br />
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**[[2gb8]] - yCcP + iso-1-cytochrome C - NMR<br />
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**[[1s6v]], [[2b11]], [[2jti]], [[2n18]] - yCcP (mutant) + iso-1-cytochrome C (mutant) <br />
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**[[5cib]], [[5cif]], [[5cig]], [[5cih]], [[4p4q]] - yCcP (mutant) + iso-1-cytochrome C<br />
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**[[5cic]], [[5cid]], [[5cie]] - yCcP (mutant) + iso-1-cytochrome C + benzene derivative<br />
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**[[1u74]], [[2b0z]], [[2b10]], [[2b12]], [[2bcn]] - yCcP + iso-1-cytochrome C (mutant)
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*CcP complex with small molecule
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**[[1cmp]] – yCcP + dimethylazolium<br />
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**[[1dcc]] – yCcP + O2<br />
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**[[1sdq]] – yCcP + NO<br />
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**[[1cpd]], [[1cpe]], [[1cpg]] – yCcP + cation<br />
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**[[1jdr]], [[1krj]] - yCcP (mutant) + cation<br />
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**[[1cpf]] – yCcP + Tris<br />
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**[[1ac4]], [[1ac8]], [[1aeb]], [[1aed]], [[1aeh]], [[1aej]], [[1aen]], [[1aev]], [[4jm5]], [[4nvb]] – yCcP (mutant) + thiazole derivative<br />
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**[[1aee]] - yCcP (mutant) + aniline<br />
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**[[1aek]], [[4jpl]] - yCcP (mutant) + indole derivative<br />
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**[[1aef]], [[1aeg]], [[1aem]], [[1aeo]], [[2anz]], [[2aqd]], [[2eun]], [[2euo]], [[2eur]], [[2rbw]], [[2rbz]], [[2rc2]], [[2y5a]], [[4jms]], [[4jmt]], [[4jmv]], [[4jn0]], [[4jqk]] - yCcP (mutant) + pyridine derivative<br />
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**[[4nvn]] - yCcP (mutant) + naphthyridine derivative<br />
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**[[2rbx]], [[4jm6]], [[4jm8]], [[4jm9]] - yCcP (mutant) + pyrimidine derivative<br />
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**[[1aeq]], [[1aes]], [[1aet]], [[1aeu]], [[1ds4]], [[1dse]], [[1dsg]], [[1dsp]], [[2euu]], [[2rby]], [[1dso]], [[4jmz]], [[4nve]], [[4nvl]], [[4nvm]], [[4nvo]] - yCcP (mutant) + imidazole derivative<br />
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**[[2as1]] - yCcP (mutant) + thiopheneneamidine<br />
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**[[2rbu]] - yCcP (mutant) + carboximidamide<br />
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**[[2as2]], [[2rc0]] - yCcP (mutant) + piperidine derivative<br />
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**[[2as3]], [[4a6z]], [[4a71]], [[4a78]], [[4jmw]] - yCcP (mutant) + phenol derivative<br />
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**[[2rc1]] - yCcP (mutant) + oxazoline<br />
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**[[2as4]], [[4jma]] - yCcP (mutant) + flurocatechol<br />
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**[[2as6]], [[2euq]], [[2eus]], [[2rbv]], [[2rbt]] - yCcP (mutant) + amine derivative<br />
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**[[2eup]], [[2eut]] - yCcP (mutant) + picoline derivative<br />
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**[[4jmb]], [[4jpt]], [[4jqj]], [[4jqm]], [[4nvd]], [[4nvg]], [[4nvh]], [[4nvi]], [[4nvk]] - yCcP (mutant) + quinoline derivative<br />
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**[[4jpu]], [[4nvc]] - yCcP (mutant) + benzamidine <br />
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**[[4nvf]] - yCcP (mutant) + MES<br />
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**[[4nvj]] - yCcP (mutant) + benzoylphosphoramidate <br />
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**[[4jqn]] - yCcP (mutant) + benzaldehyde<br />
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**[[2v2e]] - yCcP (mutant) + isoniazid<br />
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**[[1bva]] - yCcP (mutant) + Mn<br />
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**[[2icv]] – yCcP + Co<br />
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**[[1dj5]] - yCcP (mutant) + hydroxyguanidine<br />
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**[[3exb]] - yCcP (mutant) + peptide
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*Cytochrome c551 peroxidase
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**[[3hq6]], [[4aal]], [[4aam]], [[4aan]] – GsCc551P – ''Geobacter sulfurreducens''<br />
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**[[3hq7]], [[3hq8]], [[3hq9]], [[4aao]] – GsCc551P (mutant)<br />
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**[[3o5c]] – Cc551P – ''Shewanella oneidensis''
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}}
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== References ==
== References ==

Current revision

Yeast heme-containing cytochrome c peroxidase complex with O2 (PDB entry 1dcc)

Drag the structure with the mouse to rotate

References

  1. ↑ Atack JM, Kelly DJ. Structure, mechanism and physiological roles of bacterial cytochrome c peroxidases. Adv Microb Physiol. 2007;52:73-106. PMID:17027371 doi:http://dx.doi.org/10.1016/S0065-2911(06)52002-8
  2. ↑ Miller MA, Shaw A, Kraut J. 2.2 A structure of oxy-peroxidase as a model for the transient enzyme: peroxide complex. Nat Struct Biol. 1994 Aug;1(8):524-31. PMID:7664080

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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