Isoaspartyl dipeptidase

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== Structural highlights ==
== Structural highlights ==
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The <scene name='75/751803/Cv/2'>active site</scene> of aspartyl dipeptidase contains the substrate and a <scene name='75/751803/Cv/3'>binuclear metal center which activates the nucleophilic water molecule</scene><ref>PMID:15882050</ref>.
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The <scene name='75/751803/Cv/4'>active site</scene> of aspartyl dipeptidase contains the substrate and a <scene name='75/751803/Cv/5'>binuclear metal center which activates the nucleophilic water molecule</scene><ref>PMID:15882050</ref>.
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[[1po9]], [[1pok]], [[1onw]] – EcIadA – ''Escherichia coli'' <br />
[[1po9]], [[1pok]], [[1onw]] – EcIadA – ''Escherichia coli'' <br />
[[2aqo]], [[2aqv]] – EcIadA (mutant) <br />
[[2aqo]], [[2aqv]] – EcIadA (mutant) <br />
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[[1ybq]] – EcIadA (mutant) + beta-aspartylhistidine <br />
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[[5lp3]] – EcIadA – Cryo EM <br />
 +
[[5xgw]] – CpIadA – ''Colwellia psychrerythraea'' <br />
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[[5xgx]] – CpIadA (mutant) <br />
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[[1ybq]] – EcIadA (mutant) + β-Asp-His <br />
[[1poj]] – EcIadA + inhibitor<br />
[[1poj]] – EcIadA + inhibitor<br />
[[1onx]] – EcIadA + aspartate<br />
[[1onx]] – EcIadA + aspartate<br />
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[[7cdh]] – FiIadA – ''Fervidobacterium islandicum'' <br />
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[[7cf6]] – FiIadA + β-Asp-Leu <br />
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[[8dqn]] – IadA – ''Leucothrix mucor'' <br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli isoaspartyl dipeptidase complex with aspartylhistidine and Zn+2 ions (PDB code 1ybq)

Drag the structure with the mouse to rotate

3D structures of isoaspartyl dipeptidase

Updated on 12-June-2023

1po9, 1pok, 1onw – EcIadA – Escherichia coli
2aqo, 2aqv – EcIadA (mutant)
5lp3 – EcIadA – Cryo EM
5xgw – CpIadA – Colwellia psychrerythraea
5xgx – CpIadA (mutant)
1ybq – EcIadA (mutant) + β-Asp-His
1poj – EcIadA + inhibitor
1onx – EcIadA + aspartate
7cdh – FiIadA – Fervidobacterium islandicum
7cf6 – FiIadA + β-Asp-Leu
8dqn – IadA – Leucothrix mucor

References

  1. ↑ Michalska K, Brzezinski K, Jaskolski M. Crystal structure of isoaspartyl aminopeptidase in complex with L-aspartate. J Biol Chem. 2005 Aug 5;280(31):28484-91. Epub 2005 Jun 9. PMID:15946951 doi:10.1074/jbc.M504501200
  2. ↑ Marti-Arbona R, Fresquet V, Thoden JB, Davis ML, Holden HM, Raushel FM. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. Biochemistry. 2005 May 17;44(19):7115-24. PMID:15882050 doi:10.1021/bi050008r

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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