Haptoglobin receptor
From Proteopedia
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<StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'> | <StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'> | ||
== Function == | == Function == | ||
| - | '''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | + | '''Haptoglobin receptor''' or '''Iron-regulated surface determinant protein H''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. |
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]]) |
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>. |
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/7'>Heme binding in subunit β</scene>. |
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *IsdH NEAT-1 domain | + | *IsdH NEAT-1 domain 86-229 |
**[[2h3k]] – SaIsdH NEAT-1 domain – ''Staphylococcus aureus'' - NMR<BR /> | **[[2h3k]] – SaIsdH NEAT-1 domain – ''Staphylococcus aureus'' - NMR<BR /> | ||
**[[3ovu]] – SaIsdH NEAT-1 domain + Hb α + α-Hb-stabilizing protein<BR /> | **[[3ovu]] – SaIsdH NEAT-1 domain + Hb α + α-Hb-stabilizing protein<BR /> | ||
| - | **[[4wjg]] – SaIsdH NEAT-1 domain + Hb α+β + Hp + Hp-Hb receptor<BR /> | + | **[[4wjg]] – SaIsdH NEAT-1 domain 92-406 + Hb α+β + Hp + Hp-Hb receptor<BR /> |
| + | **[[3szk]] – SaIsdH NEAT-1 domain + Hb α+β<BR /> | ||
| + | **[[3s48]] – SaIsdH NEAT-1 domain + Hb α<BR /> | ||
| - | *IsdH NEAT-2 domain | + | *IsdH NEAT-2 domain 321-464 |
**[[4fc3]] – SaIsdH NEAT-2 domain + Hb α+β<BR /> | **[[4fc3]] – SaIsdH NEAT-2 domain + Hb α+β<BR /> | ||
| - | *IsdH NEAT-3 domain | + | *IsdH NEAT-3 domain 539-664 |
**[[3vua]] – SaIsdH NEAT-3 domain <BR /> | **[[3vua]] – SaIsdH NEAT-3 domain <BR /> | ||
**[[2z6f]] – SaIsdH NEAT-3 domain + heme<BR /> | **[[2z6f]] – SaIsdH NEAT-3 domain + heme<BR /> | ||
**[[3qug]], [[3quh]], [[3vtm]] – SaIsdH NEAT-3 domain + porphyrin<BR /> | **[[3qug]], [[3quh]], [[3vtm]] – SaIsdH NEAT-3 domain + porphyrin<BR /> | ||
| - | **[[3szk]] – SaIsdH NEAT-3 domain + Hb α+β<BR /> | ||
| - | **[[3s48]] – SaIsdH NEAT-3 domain + Hb α<BR /> | ||
| - | *IsdH NEAT-2-3 domain | + | *IsdH NEAT-linker-3 domain 476-656 |
| + | |||
| + | **[[7w81]] – SaIsdH NEAT-linker-3 domain + heme<BR /> | ||
| + | **[[7xld]] – SaIsdH NEAT-linker-3 domain + nanobody<BR /> | ||
| + | |||
| + | *IsdH NEAT-2-3 domain 326-660 | ||
**[[4ij2]], [[4xs0]] – SaIsdH NEAT-2-3 domain (mutant) + Hb α+β<BR /> | **[[4ij2]], [[4xs0]] – SaIsdH NEAT-2-3 domain (mutant) + Hb α+β<BR /> | ||
| - | *IsdH linker domain | + | *IsdH linker domain 467-543 |
**[[2lhr]] – SaIsdH linker domain - NMR<BR /> | **[[2lhr]] – SaIsdH linker domain - NMR<BR /> | ||
Current revision
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3D Structures of haptoglobin receptor
Updated on 07-August-2025
References
- ↑ Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296. PMID:18451305 doi:http://dx.doi.org/10.1126/science.1156296
