1z1y

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[[Image:1z1y.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax==
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|PDB= 1z1y |SIZE=350|CAPTION= <scene name='initialview01'>1z1y</scene>, resolution 2.000&Aring;
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<StructureSection load='1z1y' size='340' side='right'caption='[[1z1y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>
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<table><tr><td colspan='2'>[[1z1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z1Y FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1y OCA], [https://pdbe.org/1z1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z1y RCSB], [https://www.ebi.ac.uk/pdbsum/1z1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z1y ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z1y OCA], [http://www.ebi.ac.uk/pdbsum/1z1y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z1y RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O96555_PLAVI O96555_PLAVI]
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== Evolutionary Conservation ==
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'''Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z1y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z1y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
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==About this Structure==
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The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.,Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807<ref>PMID:16327807</ref>
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1Z1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z1Y OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16327807 16327807]
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</div>
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<div class="pdbe-citations 1z1y" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
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[[Category: Single protein]]
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[[Category: Garboczi DN]]
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[[Category: Garboczi, D N.]]
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[[Category: Klein MM]]
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[[Category: Klein, M M.]]
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[[Category: Long CA]]
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[[Category: Long, C A.]]
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[[Category: Saul AJ]]
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[[Category: Saul, A J.]]
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[[Category: Saxena AK]]
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[[Category: Saxena, A K.]]
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[[Category: Singh K]]
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[[Category: Singh, K.]]
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[[Category: Stowers AW]]
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[[Category: Stowers, A W.]]
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[[Category: Su HP]]
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[[Category: Su, H P.]]
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[[Category: four egf-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:52 2008''
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Current revision

Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax

PDB ID 1z1y

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