1z21

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[[Image:1z21.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the core domain of Yersinia pestis virulence factor YopR==
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|PDB= 1z21 |SIZE=350|CAPTION= <scene name='initialview01'>1z21</scene>, resolution 1.499&Aring;
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<StructureSection load='1z21' size='340' side='right'caption='[[1z21]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1z21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z21 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499&#8491;</td></tr>
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|GENE= yscH, lcrP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z21 OCA], [https://pdbe.org/1z21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z21 RCSB], [https://www.ebi.ac.uk/pdbsum/1z21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z21 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z21 OCA], [http://www.ebi.ac.uk/pdbsum/1z21 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z21 RCSB]</span>
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[https://www.uniprot.org/uniprot/YSCH_YERPE YSCH_YERPE] Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal structure of the core domain of Yersinia pestis virulence factor YopR'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z21_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z21 ConSurf].
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1Z21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15930010 15930010]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Austin, B P.]]
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[[Category: Austin BP]]
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[[Category: Cherry, S.]]
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[[Category: Cherry S]]
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[[Category: Schubot, F D.]]
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[[Category: Schubot FD]]
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[[Category: Tropea, J E.]]
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[[Category: Tropea JE]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh DS]]
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[[Category: plague]]
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[[Category: type iii secretion]]
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[[Category: yersinia pesti]]
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[[Category: yop]]
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[[Category: yopr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:53 2008''
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Current revision

Crystal structure of the core domain of Yersinia pestis virulence factor YopR

PDB ID 1z21

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