Mannan-binding lectin serine protease

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== Structural highlights ==
== Structural highlights ==
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<scene name='74/748867/Cv/2'>Human MASP-2 sushi 2 domain and catalytic domain complex with protease inhibitor SGPI-2</scene>. MASP-1, MASP-2 and MASP-3 are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>.
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<scene name='74/748867/Cv/2'>Human MASP-2 sushi 2 domain and catalytic domain complex with protease inhibitor SGPI-2</scene>.''' MASP-1, MASP-2 and MASP-3''' are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>.
</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Mannan-building serine protease 1
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*Mannan-binding serine protease 1
**[[4aqb]] – hMASP-1 - human<br />
**[[4aqb]] – hMASP-1 - human<br />
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**[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br />
**[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br />
**[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br />
**[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br />
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**[[5ckn]] – rMASP-1 CUB1-EGF-CUB2 domain <br />
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**[[5ckq]] – rMASP-1 CUB1-EGF-CUB2 domain <br />
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*Mannan-building serine protease 2
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*Mannan-binding serine protease 2
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**[[5jpm]], [[4fxg]] – hMASP-2 + complement C4-A <br />
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**[[5jpm]] – hMASP-2 (mutant) + complement C4-A <br />
**[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br />
**[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br />
**[[1q3x]] – hMASP-2 catalytic domain <br />
**[[1q3x]] – hMASP-2 catalytic domain <br />
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**[[1nt0]], [[5cis]], [[5ckm]], [[5ckn]] – hMASP-2 CUB1-EGF-CUB2 domain <br />
**[[1nt0]], [[5cis]], [[5ckm]], [[5ckn]] – hMASP-2 CUB1-EGF-CUB2 domain <br />
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*Mannan-building serine protease 3
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*Mannan-binding serine protease 3
**[[4kkd]] – hMASP-3 (mutant)<br />
**[[4kkd]] – hMASP-3 (mutant)<br />

Current revision

Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code 3tvj)

Drag the structure with the mouse to rotate

3D structures of mannan-binding lectin serine protease

Updated on 11-July-2024

References

  1. ↑ Thiel S, Jensen L, Degn SE, Nielsen HJ, Gal P, Dobo J, Jensenius JC. Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clin Exp Immunol. 2012 Jul;169(1):38-48. doi: 10.1111/j.1365-2249.2012.04584.x. PMID:22670777 doi:http://dx.doi.org/10.1111/j.1365-2249.2012.04584.x
  2. ↑ Frauenknecht V, Thiel S, Storm L, Meier N, Arnold M, Schmid JP, Saner H, Schroeder V. Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases. Clin Exp Immunol. 2013 Jul;173(1):112-20. doi: 10.1111/cei.12093. PMID:23607747 doi:http://dx.doi.org/10.1111/cei.12093
  3. ↑ Schwaeble W, Dahl MR, Thiel S, Stover C, Jensenius JC. The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes. Immunobiology. 2002 Sep;205(4-5):455-66. PMID:12396007 doi:http://dx.doi.org/10.1078/0171-2985-00146
  4. ↑ Heja D, Harmat V, Fodor K, Wilmanns M, Dobo J, Kekesi KA, Zavodszky P, Gal P, Pal G. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease (MASP)-1 and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2. J Biol Chem. 2012 Apr 16. PMID:22511776 doi:10.1074/jbc.M112.354332

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