Muscle LIM protein

From Proteopedia

Current revision

spinqualitylabelsall models Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry 1x4l) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Muscle LIM protein (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton[1]. For more details see Group:MUZIC:MLP and MLP. Disease Mutations in MLP are seen in cases of cardiomyopathy[2].

3D structures of muscle LIM protein

Updated on 10-July-2023

1wyh, 2d8z – hLMP 2 LIM domain – human – NMR
1x4k, 1x4l, 2ehe, 2miu - hLMP 3 LIM domain – NMR
2cuq – hLMP2 2 LIM domain – NMR
1x63, 2cup, 2cur, 2egq - hLMP 1 LIM domain – NMR
2o10 - hLMP N terminal – NMR
2o13 - hLMP C terminal – NMR

References

1. ↑ Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731
2. ↑ Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359